2. Academic Validation
  3. Evaluation of antileishmanial activity of trans-aconitic acid

Evaluation of antileishmanial activity of trans-aconitic acid

  • Biochem Med Metab Biol. 1989 Dec;42(3):171-8. doi: 10.1016/0885-4505(89)90052-2.
S Misra 1,  T Sanyal,  D Sarkar,  P K Bhattacharya,  D K Ghosh
Affiliations

Affiliation

  • 1 Department of Immunochemistry, Indian Institute of Chemical Biology, Calcutta.
PMID: 2597432 DOI: 10.1016/0885-4505(89)90052-2
Abstract

TAA, an inhibitor of the enzyme aconitase, inhibits the growth of L. donovani promastigotes. Morphogenic transformation of the amastigote to the promastigote (table; see text) form in vitro was also inhibited by 2 mM TAA. TAA also reduced multiplication of the Parasite in macrophage culture. In the hamster model of Leishmania, TAA significantly reduced the parasitic burden of liver. In acute toxicity tests with BALB/c mice no deaths were recorded even at a dose level of 2 g/kg body wt/day.

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