2. Academic Validation
  3. Epidermal growth factor receptor-targeted peptide conjugated phospholipid micelles for doxorubicin delivery

Epidermal growth factor receptor-targeted peptide conjugated phospholipid micelles for doxorubicin delivery

  • J Drug Target. 2016;24(2):111-9. doi: 10.3109/1061186X.2015.1058800.
Mingliang Fan 1,  Xiaofei Liang 1,  Danbo Yang 1,  Xiaorong Pan 1,  Zonghai Li 1,  Hongyang Wang 1,  Bizhi Shi 1
Affiliations

Affiliation

  • 1 a State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine , Shanghai , China.
PMID: 26176268 DOI: 10.3109/1061186X.2015.1058800
Abstract

Specific targeting of tumor cells to achieve higher drug levels in tumor tissue and to overcome side effects is the major goal in Cancer chemotherapy. In this study, we used a tumor targeting peptide, GE11, to conjugate onto the surface of doxorubicin encapsulated phospholipid micelles. The GE11 peptide triggered specific binding to epidermal growth factor receptor (EGFR), leading to enhanced cellular uptake and cytotoxicity in vitro and highly accumulation in the tumors in vivo. The results indicated that GE11 conjugated phospholipid micelles should have potential applications in Cancer therapy.

Keywords

Doxorubicin; GE11; epidermal growth factor receptor; micelles; targeted drug delivery.

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