2. Academic Validation
  3. ERK-dependent brain-derived neurotrophic factor regulation by hesperidin in mice exposed to chronic mild stress

ERK-dependent brain-derived neurotrophic factor regulation by hesperidin in mice exposed to chronic mild stress

  • Brain Res Bull. 2016 Jun;124:40-7. doi: 10.1016/j.brainresbull.2016.03.016.
Cheng-Fu Li 1,  Shao-Mei Chen 2,  Xue-Mei Chen 2,  Rong-Hao Mu 3,  Shuang-Shuang Wang 3,  Di Geng 3,  Qing Liu 3,  Li-Tao Yi 4
Affiliations

Affiliations

  • 1 Xiamen Hospital of Traditional Chinese Medicine, Xiamen 361009, Fujian province, PR China. Electronic address: [email protected].
  • 2 Xiamen Hospital of Traditional Chinese Medicine, Xiamen 361009, Fujian province, PR China.
  • 3 Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University, Xiamen 361021, Fujian province, PR China.
  • 4 Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University, Xiamen 361021, Fujian province, PR China. Electronic address: [email protected].
PMID: 27018164 DOI: 10.1016/j.brainresbull.2016.03.016
Abstract

A previous study found that the antidepressant-like effects of ethanolic extracts from Hemerocallis citrina are predominantly related to the flavonoid, hesperidin. The study herein aimed to explore the antidepressant-like mechanism of hesperidin in mice induced by chronic mild stress (CMS). The results indicated that hesperidin reversed the reduction of sucrose preference and the elevation of immobility time in mice induced by CMS. In addition, the increase in serum corticosterone levels and decrease in hippocampal extracellular signal-regulated kinase (ERK) phosphorylation and brain-derived neurotrophic factor (BDNF) levels in CMS mice were also ameliorated by hesperidin treatment. In contrast, improvement by hesperidin was suppressed by pretreatment with ERK Inhibitor SL327. Taken together, our findings confirmed the antidepressant-like effect of hesperidin and indicated that hesperidin-induced BDNF up-regulation was mediated in an ERK-dependent manner.

Keywords

Antidepressant; Brain-derived neurotrophic factor; Chronic mild stress; Corticosterone; Hemerocallis citrina; Hesperidin.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-15437
    ≥98.0%, MEK Inhibitor
    MEK