2. Academic Validation
  3. Engineering Lysosome-Targeting BODIPY Nanoparticles for Photoacoustic Imaging and Photodynamic Therapy under Near-Infrared Light

Engineering Lysosome-Targeting BODIPY Nanoparticles for Photoacoustic Imaging and Photodynamic Therapy under Near-Infrared Light

  • ACS Appl Mater Interfaces. 2016 May 18;8(19):12039-47. doi: 10.1021/acsami.6b02721.
Wenbo Hu 1,  Hengheng Ma 1,  Bing Hou 1,  Hui Zhao 1,  Yu Ji 1,  Rongcui Jiang 1,  Xiaoming Hu 1,  Xiaomei Lu 2,  Lei Zhang 1,  Yufu Tang 1,  Quli Fan 1,  Wei Huang 2
Affiliations

Affiliations

  • 1 Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications , Nanjing 210023, China.
  • 2 Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (NanjingTech) , Nanjing 211816, China.
PMID: 27123534 DOI: 10.1021/acsami.6b02721
Abstract

Developing lysosome-targeting organic nanoparticles combined with photoacoustic imaging (PAI) and photodynamic therapy (PDT) functions toward personalized medicine are highly desired yet challenging. Here, for the first time, lysosome-targeting BODIPY nanoparticles were engineered by encapsulating near-infrared (NIR) absorbed BODIPY dye within amphiphilic DSPE-mPEG5000 for high-performing lysosomal PAI and acid-activatable PDT against Cancer cells under NIR light.

Keywords

lysosome-targeting; near-infrared absorption; photoacoustic imaging; photodynamic therapy; theranostic nanoparticles.

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