2. Academic Validation
  3. Inhibition of LpxC Increases Antibiotic Susceptibility in Acinetobacter baumannii

Inhibition of LpxC Increases Antibiotic Susceptibility in Acinetobacter baumannii

  • Antimicrob Agents Chemother. 2016 Jul 22;60(8):5076-9. doi: 10.1128/AAC.00407-16.
Meritxell García-Quintanilla 1,  José M Caro-Vega 1,  Marina R Pulido 1,  Patricia Moreno-Martínez 1,  Jerónimo Pachón 1,  Michael J McConnell 2
Affiliations

Affiliations

  • 1 Unit of Infectious Diseases, Microbiology, and Preventive Medicine and Biomedical Institute of Seville (IBiS), University Hospital Virgen del Rocío/CSIC/University of Sevilla, Seville, Spain.
  • 2 Unit of Infectious Diseases, Microbiology, and Preventive Medicine and Biomedical Institute of Seville (IBiS), University Hospital Virgen del Rocío/CSIC/University of Sevilla, Seville, Spain [email protected].
PMID: 27270288 DOI: 10.1128/AAC.00407-16
Abstract

LpxC inhibitors have generally shown poor in vitro activity against Acinetobacter baumannii We show that the LpxC inhibitor PF-5081090 inhibits lipid A biosynthesis, as determined by silver staining and measurements of endotoxin levels, and significantly increases cell permeability. The presence of PF-5081090 at 32 mg/liter increased susceptibility to rifampin, vancomycin, azithromycin, imipenem, and amikacin but had no effect on susceptibility to ciprofloxacin and tigecycline. Potentiating existing Antibiotics with LpxC inhibitors may represent an alternative treatment strategy for multidrug-resistant A. baumannii.

Figures
Products