2. Academic Validation
  3. Structural Features and Potent Antidepressant Effects of Total Sterols and β-sitosterol Extracted from Sargassum horneri

Structural Features and Potent Antidepressant Effects of Total Sterols and β-sitosterol Extracted from Sargassum horneri

  • Mar Drugs. 2016 Jun 28;14(7):123. doi: 10.3390/md14070123.
Donghai Zhao 1,  Lianwen Zheng 2,  Ling Qi 3,  Shuran Wang 4,  Liping Guan 5,  Yanan Xia 6,  Jianhui Cai 7
Affiliations

Affiliations

  • 1 The Basic Medical College, Jilin Medical University, Jilin 132013, China. [email protected].
  • 2 The Second Hospital, Jilin University, Changchun 130041, China. [email protected].
  • 3 The Basic Medical College, Jilin Medical University, Jilin 132013, China. [email protected].
  • 4 The Basic Medical College, Jilin Medical University, Jilin 132013, China. [email protected].
  • 5 Food and Pharmacy College, Zhejiang Ocean University, Zhoushan 316022, China. [email protected].
  • 6 Food and Pharmacy College, Zhejiang Ocean University, Zhoushan 316022, China. [email protected].
  • 7 The Basic Medical College, Jilin Medical University, Jilin 132013, China. [email protected].
PMID: 27367705 DOI: 10.3390/md14070123
Abstract

The purified total sterols and β-sitosterol extracted from Sargassum horneri were evaluated for their antidepressant-like activity using the forced swim test (FST) and tail suspension test (TST) in mice. Total sterols and β-sitosterol significantly reduced the immobility time in the FST and TST. Total sterols were administered orally for 7 days at doses of 50, 100, and 200 mg/kg, and β-sitosterol was administered intraperitoneally at doses of 10, 20, and 30 mg/kg. β-sitosterol had no effect on locomotor activity in the open field test. In addition, total sterols and β-sitosterol significantly increased NE, 5-HT, and the metabolite 5-HIAA in the mouse brain, suggesting that the antidepressant-like activity may be mediated through these neurotransmitters.

Keywords

FST; Sargassum horneri; TST; monoamine neurotransmitters; sterols; β-sitosterol.

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