2. Academic Validation
  3. Two new limonoids isolated from the fuits of Melia toosendan

Two new limonoids isolated from the fuits of Melia toosendan

  • Chin J Nat Med. 2016 Sep;14(9):692-696. doi: 10.1016/S1875-5364(16)30082-6.
Qiong Zhang 1,  Qing-Hong Zheng 2,  Jing-Yu Liang 3,  Qing-Shan Li 2,  Zhi-Da Min 3
Affiliations

Affiliations

  • 1 Department of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China. Electronic address: [email protected].
  • 2 Department of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China.
  • 3 Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
PMID: 27667515 DOI: 10.1016/S1875-5364(16)30082-6
Abstract

In the present study, two new limonoids, 1α, 7α-dihydroxyl-3α-acetoxyl-12α-ethoxylnimbolinin (1) and 1α-tigloyloxy-3α-acetoxyl-7α-hydroxyl-12β-ethoxylnimbolinin (2), together with Other four known limonoids (3-6), were isolated from the fruits of Melia toosendan. Their structures were elucidated by means of extensive spectroscopic analyses (NMR and ESI-MS) and comparisons with the data reported in the literature. The isolated compounds were evaluated for their Antibacterial activities. Compound 4 exhibited significant Antibacterial activity against an oral pathogen, Porphyromonas gingivalis ATCC 33277, with an MIC value of 15.2 μg·mL(-1). Compound 2 was also active against P. gingivalis ATCC 33277, with an MIC value of 31.25 μg·mL(-1). In conlcusion, our resutls indicate that these compounds may provide a basis for future development of novel Antibiotics.

Keywords

Antibacterial; Limonoid; Melia toosendan; Meliaceae; Oral pathogen.

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