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Cat. No.: HY-N18272

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1α-Benzoyloxy-3α-acetoxyl-7α-hydroxy-12β-ethoxynimbolinin

1α-Benzoyloxy-3α-acetoxyl-7α-hydroxy-12β-ethoxynimbolinin is a nimbolinin-type limonoid and cytotoxin, found in the fruits of Melia toosendan. 1α-Benzoyloxy-3α-acetoxyl-7α-hydroxy-12β-ethoxynimbolinin exhibits in vitro cytotoxicity against human hepatocellular carcinoma, human lung cancer, and human breast cancer cells. 1α-Benzoyloxy-3α-acetoxyl-7α-hydroxy-12β-ethoxynimbolinin can be used for the research of hepatocellular carcinoma, lung cancer, breast cancer.

For research use only. We do not sell to patients.

CAS No.: 1613615-09-0
Formula: C₃₇H₄₆O₉
Molecular Weight:634.76

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (278 KB)

1α-Benzoyloxy-3α-acetoxyl-7α-hydroxy-12β-ethoxynimbolinin Chemical Structure

CAS No.: 1613615-09-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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Chemical Information
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Biological Activity

Description

In Vitro

1α-Benzoyloxy-3α-acetoxyl-7α-hydroxy-12β-ethoxynimbolinin shows selective cytotoxicity against SMMC-7721, A-549, and MCF-7 human tumor cell lines with IC₅₀ values of 21.2, 39.5, and 26.1 μM, respectively, and no cytotoxicity (IC₅₀ > 40 μM) against HL-60 and SW480 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1613615-09-0
Molecular Weight 634.76
Formula C₃₇H₄₆O₉
SMILES

C[C@@]12[C@]3([H])[C@@]([C@@H](C[C@@H]1OC(C4=CC=CC=C4)=O)OC(C)=O)(CO[C@@]3([H])[C@H]([C@@]5([C@]2([H])C[C@H](O[C@]6([H])C5=C([C@H](C7=COC=C7)C6)C)OCC)C)O)C
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Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (278 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang Q, et al. Two new limonoids isolated from the fuits of Melia toosendan. Chin J Nat Med. 2016 Sep;14(9):692-696.
[Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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1α-Benzoyloxy-3α-acetoxyl-7α-hydroxy-12β-ethoxynimbolinin

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1α-Benzoyloxy-3α-acetoxyl-7α-hydroxy-12β-ethoxynimbolinin

Biological Activity

Description

In Vitro

Chemical Information

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1α-Benzoyloxy-3α-acetoxyl-7α-hydroxy-12β-ethoxynimbolinin Related Classifications

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