2. Academic Validation
  3. Role of Osteogenic Growth Peptide (OGP) and OGP(10-14) in Bone Regeneration: A Review

Role of Osteogenic Growth Peptide (OGP) and OGP(10-14) in Bone Regeneration: A Review

  • Int J Mol Sci. 2016 Nov 22;17(11):1885. doi: 10.3390/ijms17111885.
Suzane C Pigossi 1 2,  Marcell C Medeiros 3,  Sybele Saska 4,  Joni A Cirelli 5,  Raquel M Scarel-Caminaga 6 7
Affiliations

Affiliations

  • 1 Department of Diagnosis and Surgery, School of Dentistry at Araraquara, UNESP-São Paulo State University, Humaita St, 1680, CEP 14801-903 Araraquara, São Paulo, Brazil. [email protected].
  • 2 Department of Morphology, School of Dentistry, UNESP- São Paulo State University, Humaita St, 1680, CEP 14801-903 Araraquara, São Paulo, Brazil. [email protected].
  • 3 Department of Diagnosis and Surgery, School of Dentistry at Araraquara, UNESP-São Paulo State University, Humaita St, 1680, CEP 14801-903 Araraquara, São Paulo, Brazil. [email protected].
  • 4 Department of General and Inorganic Chemistry, Institute of Chemistry, UNESP-São Paulo State University, Professor Francisco Degni St, 55, CEP 14800-900 Araraquara, São Paulo, Brazil. [email protected].
  • 5 Department of Diagnosis and Surgery, School of Dentistry at Araraquara, UNESP-São Paulo State University, Humaita St, 1680, CEP 14801-903 Araraquara, São Paulo, Brazil. [email protected].
  • 6 Department of Diagnosis and Surgery, School of Dentistry at Araraquara, UNESP-São Paulo State University, Humaita St, 1680, CEP 14801-903 Araraquara, São Paulo, Brazil. [email protected].
  • 7 Department of Morphology, School of Dentistry, UNESP- São Paulo State University, Humaita St, 1680, CEP 14801-903 Araraquara, São Paulo, Brazil. [email protected].
PMID: 27879684 DOI: 10.3390/ijms17111885
Abstract

Bone regeneration is a process that involves several molecular mediators, such as growth factors, which directly affect the proliferation, migration and differentiation of bone-related cells. The osteogenic growth peptide (OGP) and its C-terminal pentapeptide OGP(10-14) have been shown to stimulate the proliferation, differentiation, Alkaline Phosphatase activity and matrix mineralization of osteoblastic lineage cells. However, the exact molecular mechanisms that promote osteoblastic proliferation and differentiation are not completely understood. This review presents the main chemical characteristics of OGP and/or OGP(10-14), and also discusses the potential molecular pathways induced by these growth factors to promote proliferation and differentiation of osteoblasts. Furthermore, since these Peptides have been extensively investigated for bone tissue engineering, the clinical applications of these Peptides for bone regeneration are discussed.

Keywords

biocompatible materials; bone regeneration; osteoblasts; osteogenic growth peptide.

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