Osteogenic Growth Peptide, OGP
Based on 2 publication(s) in Google Scholar
Osteogenic Growth Peptide, OGP is a short, naturally occurring 14-mer growth factor peptide found in serum at μM concentrations.
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- 純度 : 99.23%
- CAS 番号: 132996-61-3
- 分子式: C68H110N22O18
- 分子量:1523.74
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保管条件:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
MedChemExpress（MCE）の使用を引用している文献 Osteogenic Growth Peptide, OGP
MoreEndogenous Metabolite アイソフォーム固有の製品をすべて表示
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生物活性
製品説明
体外実験
Osteogenic Growth Peptide (OGP) regulates proliferation, differentiation, and matrix mineralization in osteoblast lineage cells. The active portion of OGP, the OGP(10-14) region, is cleaved from the peptide and binds to the OGP receptor which activates the MAP kinase, the Src, and the RhoA pathways[1]. Osteogenic Growth Peptide (OGP) is a native molecule with a primary structure identical to the C-terminus of histone H4, whose sequence contains a highly conserved 14-amino acid motif (NH2-ALKRQGRTLYGFGG-OH). This peptide is isolated from blood during osteogenic remodeling of post-ablation of marrow regeneration. The osteogenic growth peptide (OGP) and its C-terminal pentapeptide OGP(10-14) have been shown to stimulate the proliferation, differentiation, alkaline phosphatase activity and matrix mineralization of osteoblastic lineage cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 132996-61-3
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性状 Solid
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分子量 1523.74
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分子式 C68H110N22O18
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Color White to off-white
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配列
Ala-Leu-Lys-Arg-Gln-Gly-Arg-Thr-Leu-Tyr-Gly-Phe-Gly-Gly
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シーケンスの短縮
ALKRQGRTLYGFGG
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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Heliyon
Osteogenic growth peptide enhances osteogenic differentiation of human periodontal ligament stem cells. [Abstract]2022 Jul 12;8(7):e09936. PMID: 35874053
溶剤 & 溶解度
体外:
H2O : 100 mg/mL (65.63 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Moore NM, et al. The use of immobilized osteogenic growth peptide on gradient substrates synthesized via clickchemistry to enhance MC3T3-E1 osteoblast proliferation. Biomaterials. 2010 Mar;31(7):1604-11. [Content Brief]
[2]. Pigossi SC, et al. Role of Osteogenic Growth Peptide (OGP) and OGP(10-14) in Bone Regeneration: A Review. Int J Mol Sci. 2016 Nov 22;17(11). pii: E1885. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.6563 mL | 3.2814 mL | 6.5628 mL | 16.4070 mL |
| 5 mM | 0.1313 mL | 0.6563 mL | 1.3126 mL | 3.2814 mL | |
| 10 mM | 0.0656 mL | 0.3281 mL | 0.6563 mL | 1.6407 mL | |
| 15 mM | 0.0438 mL | 0.2188 mL | 0.4375 mL | 1.0938 mL | |
| 20 mM | 0.0328 mL | 0.1641 mL | 0.3281 mL | 0.8203 mL | |
| 25 mM | 0.0263 mL | 0.1313 mL | 0.2625 mL | 0.6563 mL | |
| 30 mM | 0.0219 mL | 0.1094 mL | 0.2188 mL | 0.5469 mL | |
| 40 mM | 0.0164 mL | 0.0820 mL | 0.1641 mL | 0.4102 mL | |
| 50 mM | 0.0131 mL | 0.0656 mL | 0.1313 mL | 0.3281 mL | |
| 60 mM | 0.0109 mL | 0.0547 mL | 0.1094 mL | 0.2734 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Osteogenic Growth Peptide, OGP 関連分類
HY-P1563 関連分類
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