Osteogenic Growth Peptide, OGP
Based on 2 publication(s) in Google Scholar
Osteogenic Growth Peptide, OGP is a short, naturally occurring 14-mer growth factor peptide found in serum at μM concentrations.
For research use only. We do not sell to patients.
- Purity: 99.23%
- CAS No.: 132996-61-3
- Formula: C68H110N22O18
- Molecular Weight:1523.74
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Storage:
Sealed storage, away from moisture.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Osteogenic Growth Peptide, OGP
MoreAll Endogenous Metabolite Isoforms
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Biological Activity
Osteogenic Growth Peptide (OGP) regulates proliferation, differentiation, and matrix mineralization in osteoblast lineage cells. The active portion of OGP, the OGP(10-14) region, is cleaved from the peptide and binds to the OGP receptor which activates the MAP kinase, the Src, and the RhoA pathways[1]. Osteogenic Growth Peptide (OGP) is a native molecule with a primary structure identical to the C-terminus of histone H4, whose sequence contains a highly conserved 14-amino acid motif (NH2-ALKRQGRTLYGFGG-OH). This peptide is isolated from blood during osteogenic remodeling of post-ablation of marrow regeneration. The osteogenic growth peptide (OGP) and its C-terminal pentapeptide OGP(10-14) have been shown to stimulate the proliferation, differentiation, alkaline phosphatase activity and matrix mineralization of osteoblastic lineage cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 132996-61-3
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Appearance Solid
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Molecular Weight 1523.74
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Formula C68H110N22O18
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Color White to off-white
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Sequence
Ala-Leu-Lys-Arg-Gln-Gly-Arg-Thr-Leu-Tyr-Gly-Phe-Gly-Gly
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Sequence Shortening
ALKRQGRTLYGFGG
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Sealed storage, away from moisture
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Publications (2)
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Journal Impact Factor
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Most Recent
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Heliyon
Osteogenic growth peptide enhances osteogenic differentiation of human periodontal ligament stem cells. [Abstract]2022 Jul 12;8(7):e09936. PMID: 35874053
Solvent & Solubility
H2O : 100 mg/mL (65.63 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Moore NM, et al. The use of immobilized osteogenic growth peptide on gradient substrates synthesized via clickchemistry to enhance MC3T3-E1 osteoblast proliferation. Biomaterials. 2010 Mar;31(7):1604-11. [Content Brief]
[2]. Pigossi SC, et al. Role of Osteogenic Growth Peptide (OGP) and OGP(10-14) in Bone Regeneration: A Review. Int J Mol Sci. 2016 Nov 22;17(11). pii: E1885. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| H2O | 1 mM | 0.6563 mL | 3.2814 mL | 6.5628 mL | 16.4070 mL |
| 5 mM | 0.1313 mL | 0.6563 mL | 1.3126 mL | 3.2814 mL | |
| 10 mM | 0.0656 mL | 0.3281 mL | 0.6563 mL | 1.6407 mL | |
| 15 mM | 0.0438 mL | 0.2188 mL | 0.4375 mL | 1.0938 mL | |
| 20 mM | 0.0328 mL | 0.1641 mL | 0.3281 mL | 0.8203 mL | |
| 25 mM | 0.0263 mL | 0.1313 mL | 0.2625 mL | 0.6563 mL | |
| 30 mM | 0.0219 mL | 0.1094 mL | 0.2188 mL | 0.5469 mL | |
| 40 mM | 0.0164 mL | 0.0820 mL | 0.1641 mL | 0.4102 mL | |
| 50 mM | 0.0131 mL | 0.0656 mL | 0.1313 mL | 0.3281 mL | |
| 60 mM | 0.0109 mL | 0.0547 mL | 0.1094 mL | 0.2734 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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