2. Academic Validation
  3. Isoxazole ring as a useful scaffold in a search for new therapeutic agents

Isoxazole ring as a useful scaffold in a search for new therapeutic agents

  • Eur J Med Chem. 2017 Sep 8;137:292-309. doi: 10.1016/j.ejmech.2017.06.002.
Angelika Sysak 1,  Bożena Obmińska-Mrukowicz 2
Affiliations

Affiliations

  • 1 Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, ul. Norwida 31, 50-375 Wrocław, Poland. Electronic address: [email protected].
  • 2 Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Wrocław University of Environmental and Life Sciences, ul. Norwida 31, 50-375 Wrocław, Poland.
PMID: 28605676 DOI: 10.1016/j.ejmech.2017.06.002
Abstract

Due to its relatively easy synthesis, isoxazole ring has been as an object of interest for chemists and pharmacologists from research groups all over the world. Its chemical modifications include both connection of isoxazole with other aromatic, heteroaromatic or non aromatic rings and substitution with different alkyl groups. Thanks to their usually low cytotoxicity, isoxazole derivatives are still popular scaffolds for the development of new agents with variable biological activities, such as antimicrobial, Antiviral, Anticancer, anti-inflammatory, immunomodulatory, anticonvulsant or anti-diabetic properties. This review discusses the chemical structure of recently developed isoxazole derivatives with regards to their activity and potential therapeutic use.

Keywords

Chemical synthesis; Isoxazole; Substituted isoxazoles; Therapeutic agents.

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