2. Academic Validation
  3. Antibacterial Activity of Hydroxytyrosol Acetate from Olive Leaves (Olea Europaea L.)

Antibacterial Activity of Hydroxytyrosol Acetate from Olive Leaves (Olea Europaea L.)

  • Nat Prod Res. 2018 Aug;32(16):1967-1970. doi: 10.1080/14786419.2017.1356830.
Jianteng Wei 1 2 3,  Shuxian Wang 4,  Dong Pei 2 3,  Liangjing Qu 4,  Ya Li 1,  Jianjun Chen 1,  Duolong Di 2 3,  Kun Gao 1
Affiliations

Affiliations

  • 1 a State Key Laboratory of Applied Organic Chemistry , College of Chemistry and Chemical Engineering, Lanzhou University , Lanzhou , P.R. China.
  • 2 b CAS Key Laboratory of Chemistry of Northwestern Plant Resources and Key Laboratory for Natural Medicine of Gansu Province , Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences(CAS) , Lanzhou , P.R. China.
  • 3 c Center of Resource Chemical & New Material , Qingdao , P.R. China.
  • 4 d Center of Fishery Disease and Drug , Marine Biology Institute of Shandong Province , Qingdao , P.R. China.
PMID: 28768425 DOI: 10.1080/14786419.2017.1356830
Abstract

Vibrio spp. are pathogens of many Bacterial diseases which have caused great economic losses in marine aquaculture. The strategy of alternative medical treatment that is utilised by herbalists has expanded in the past decade. The aim of our study is to discover the Antibacterial molecules against Vibrio spp. Bacterial growth inhibition, membrane permeabilisation assessment and DNA interaction assays, as well as Agarose gel electrophoresis, were employed to elucidate the Antibacterial activity of hydroxytyrosol acetate. Results showed that hydroxytyrosol acetate had Antibacterial activity against Vibrio spp. and it played the role via increasing Bacterial membrane permeabilisation. The DNA interaction assay and Agarose gel electrophoresis revealed that hydroxytyrosol acetate interacted with DNA. Hydroxytyrosol acetate enhanced the fluorescent intensity of DNA binding molecules and mediated supercoiled DNA relaxation. The present study provides more evidence that hydroxytyrosol acetate is a novel Antibacterial candidate against Vibrio spp.

Keywords

DNA interaction; Hydroxytyrosol acetate; antibacterial activity; olive leaves.

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