2. Academic Validation
  3. Cornusides A-O, Bioactive Iridoid Glucoside Dimers from the Fruit of Cornus officinalis

Cornusides A-O, Bioactive Iridoid Glucoside Dimers from the Fruit of Cornus officinalis

  • J Nat Prod. 2017 Dec 22;80(12):3103-3111. doi: 10.1021/acs.jnatprod.6b01127.
Xian-Sheng Ye 1 2,  Jun He 3,  Yung-Chi Cheng 4,  Lei Zhang 5,  Hao-Yi Qiao 1,  Xue-Ge Pan 1,  Jia Zhang 1,  Shu-Na Liu 1,  Wei-Ku Zhang 2,  Jie-Kun Xu 1
Affiliations

Affiliations

  • 1 School of Life Sciences & School of Chinese Medicine Sciences, Beijing University of Chinese Medicine , Beijing 100029, People's Republic of China.
  • 2 Institute of Clinical Medical Sciences, China-Japan Friendship Hospital , Beijing 100029, People's Republic of China.
  • 3 Department of Pharmacy, China-Japan Friendship Hospital , Beijing 100029, People's Republic of China.
  • 4 Department of Pharmacology, Yale University School of Medicine , New Haven, Connecticut 06520, United States.
  • 5 Department of Pharmacy, Beijing Shijitan Hospital, Capital Medical University , Beijing 100038, People's Republic of China.
PMID: 29140705 DOI: 10.1021/acs.jnatprod.6b01127
Abstract

Fifteen new and rare iridoid glucoside dimers, cornusides A-O (1-15), and 10 known iridoid glucosides (16-25) were isolated from the fruit of Cornus officinalis. These new chemical structures were established through spectroscopic analysis (UV, IR, HRESIMS, 1D and 2D NMR). Compounds 1-25 were tested for their inhibitory activities by measuring IL-6-induced STAT3 promoter activity in HepG2 cells, and 3, 12, 17, 22, and 23 showed inhibitory effects, with IC50 values of 11.9, 12.2, 14.0, 7.0, and 6.9 μM, respectively.

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