2. Academic Validation
  3. Regulation and function of interleukin-36 cytokines

Regulation and function of interleukin-36 cytokines

  • Immunol Rev. 2018 Jan;281(1):169-178. doi: 10.1111/imr.12610.
Esen Yonca Bassoy 1,  Jennifer E Towne 2,  Cem Gabay 1
Affiliations

Affiliations

  • 1 Division of Rheumatology, Department of Internal Medicine Specialties & Department of Pathology-Immunology, University Hospitals of Geneva and University of Geneva, Geneva, Switzerland.
  • 2 Immunology Discovery, Janssen Research and Development, San Diego, CA, USA.
PMID: 29247994 DOI: 10.1111/imr.12610
Abstract

The interleukin (IL)-36 cytokines include 3 agonists, IL-36α, IL-36β, and IL-36γ that bind to a common receptor composed of IL-36R and IL-1RAcP to stimulate inflammatory responses. IL-36RA is a natural antagonist that binds to IL-36R, but does not recruit the co-receptor IL-1RAcP and does not stimulate any intracellular responses. The IL-36 cytokines are expressed predominantly by epithelial cells and act on a number of cells including immune cells, epithelial cells, and fibroblasts. Processing of the N-terminus is required for full agonist or antagonist activity for all IL-36 members. The role of IL-36 has been extensively demonstrated in the skin where it can act on keratinocytes and immune cells to induce a robust inflammatory response that has been implicated in psoriatic disorders. Emerging data also suggest a role for this cytokine family in pulmonary and intestinal physiology and pathology.

Keywords

IL-1 family; inflammation; intestine; lung; psoriasis.

Figures
Products