2. Academic Validation
  3. Theranostic micelles combined with multiple strategies to effectively overcome multidrug resistance

Theranostic micelles combined with multiple strategies to effectively overcome multidrug resistance

  • Nanomedicine (Lond). 2018 Jul;13(13):1517-1533. doi: 10.2217/nnm-2017-0393.
Dan Zhao 1,  Qing Chen 1,  Hua Song 1,  Shuting Luo 1,  Pingyun Ge 1,  Yingjun Wang 1,  Jinyuan Ma 1,  Zhi Li 1,  Xuemin Gao 1,  Xuemei Zhao 1,  Xiayiding Subinuer 1,  Huayu Yang 1,  Xiaojuan Jiang 1,  Yanxin Chen 1,  Xuan Zhu 1
Affiliations

Affiliation

  • 1 Fujian Provincial Key Laboratory of Innovative Drug Target Research, School of Pharmaceutical Sciences, Xiamen University, Xiamen, Fujian, PR China.
PMID: 30028224 DOI: 10.2217/nnm-2017-0393
Abstract

Aim: To develop precise targeting and versatile Fe3O4@SiO2-P123/PTX-ZnPc nanoparticles (FSP-PTX-ZnPc NPs) to reverse paclitaxel (PTX)-induced multidrug resistance in breast Cancer.

Materials & methods: PTX and zinc (II) phthalocyanine (ZnPc) co-loaded FSP-PTX-ZnPc NPs were designed. The resulting multifunctional NPs were evaluated systematically in vitro and in vivo, and the mechanism of drug-resistance reversal was investigated.

Results: The NPs enhanced drug uptake in MCF-7/PDR cells by increasing drug solubility and impairing P-glycoprotein efflux. Additionally, magnetic targeting and enhanced permeation and retention (EPR) effect enhanced drug accumulation in tumor, facilitating the chemotherapeutic and photodynamic therapy effects. Moreover, FSP-PTX-ZnPc NPs could penetrate the blood-brain barrier, a desirable trait for brain disease therapy.

Conclusion: The multifunctional FSP-PTX-ZnPc NPs are an effective tool for overcoming drug resistance in breast Cancer.

Keywords

breast cancer; drug resistance; magnetic targeting; nanoparticles; paclitaxel; photodynamic therapy; zinc(II) phthalocyanine.

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