2. Academic Validation
  3. Isosteroidal alkaloids from the bulbs of Fritillaria tortifolia

Isosteroidal alkaloids from the bulbs of Fritillaria tortifolia

  • Fitoterapia. 2018 Nov:131:112-118. doi: 10.1016/j.fitote.2018.10.019.
Zhu Hu 1,  Jian-Fa Zong 1,  Abulimiti Yili 2,  Mei-Hua Yu 1,  Haji Akber Aisa 3,  Ai-Jun Hou 4
Affiliations

Affiliations

  • 1 Department of Pharmacognosy, School of Pharmacy, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 201203, PR China.
  • 2 Key Laboratory of Plant Resources and Chemistry in Arid Zone and State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, PR China.
  • 3 Key Laboratory of Plant Resources and Chemistry in Arid Zone and State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, PR China. Electronic address: [email protected].
  • 4 Department of Pharmacognosy, School of Pharmacy, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 201203, PR China. Electronic address: [email protected].
PMID: 30336193 DOI: 10.1016/j.fitote.2018.10.019
Abstract

Three new isosteroidal Alkaloids, frititorines A-C (1-3), were isolated from the bulbs of Fritillaria tortifolia, together with ten known ones (4-13). Their structures were elucidated by extensive spectroscopic analyses, chemical methods, and single-crystal X-ray crystallographic analysis. Compound 1 is the first 5β-cevanine alkaloid with a cis A/B ring junction from the Fritillaria genus. Compound 2 is the first example of glycosylated isosteroidal alkaloid N-oxide. Compound 1 showed significant relaxant effect on Ach-induced tracheal contraction with pA2 and EC50 values equivalent to those of aminophylline.

Keywords

Fritillaria tortifolia; Frititorines A-C; Isosteroidal alkaloids; Tracheal relaxant effect.

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