2. Academic Validation
  3. Curcumin's Metabolites, Tetrahydrocurcumin and Octahydrocurcumin, Possess Superior Anti-inflammatory Effects in vivo Through Suppression of TAK1-NF-κB Pathway

Curcumin's Metabolites, Tetrahydrocurcumin and Octahydrocurcumin, Possess Superior Anti-inflammatory Effects in vivo Through Suppression of TAK1-NF-κB Pathway

  • Front Pharmacol. 2018 Oct 17:9:1181. doi: 10.3389/fphar.2018.01181.
Zhen-Biao Zhang 1 2,  Dan-Dan Luo 1,  Jian-Hui Xie 3,  Yan-Fang Xian 2,  Zheng-Quan Lai 2 4,  Yu-Hong Liu 1,  Wei-Hai Liu 5,  Jian-Nan Chen 6,  Xiao-Ping Lai 1 7,  Zhi-Xiu Lin 1 2,  Zi-Ren Su 1 7
Affiliations

Affiliations

  • 1 Guangdong Provincial Key Laboratory of New Drug Development and Research of Chinese Medicine, Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China.
  • 2 School of Chinese Medicine, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
  • 3 Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, The Second Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China.
  • 4 Department of Pharmacy, Shenzhen University General Hospital, Shenzhen University, Shenzhen, China.
  • 5 Guangdong Food and Drug Vocational College, Guangzhou, China.
  • 6 Higher Education Institute and Development Research of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China.
  • 7 Dongguan Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine, Dongguan, China.
PMID: 30386242 DOI: 10.3389/fphar.2018.01181
Abstract

Curcumin (CUR), a promising naturally occurring dietary compound, is commonly recognized as the potential anti-inflammatory agent. While the application of CUR was hampered by its low stability and poor systemic bioavailability, it has been suggested that the biological activities of CUR are intimately related to its metabolites. In the current investigation, we aimed to comparatively explore the anti-inflammatory effects of tetrahydrocurcumin (THC), octahydrocurcumin (OHC), and CUR, and to elucidate the underlying action mechanisms on experimental mice models of acute inflammation, i.e., xylene-induced ear edema, acetic acid-induced vascular permeability, and carrageenan-induced paw edema. The results showed that THC and OHC exerted significant and dose-dependent inhibitions on the formation of ear edema induced by xylene and paw edema provoked by carrageenan and inhibited the Evans blue dye leakage in peritoneal cavity elicited by acetic acid. Moreover, THC and OHC treatments were more effective than CUR in selectively inhibiting the expression of cyclooxygenase 2 (COX-2) and suppressing nuclear factor-κB (NF-κB) pathways via transforming growth factor β activated kinase-1 (TAK1) inactivation in the carrageenan-induced mouse paw edema model.

Keywords

COX-2; TAK1-NF-κB pathway; curcumin; inflammation; octahydrocucumin; tetrahydrocurcumin.

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