2. Academic Validation
  3. Antimicrobial tunicamycin derivatives from the deep sea-derived Streptomyces xinghaiensis SCSIO S15077

Antimicrobial tunicamycin derivatives from the deep sea-derived Streptomyces xinghaiensis SCSIO S15077

  • Nat Prod Res. 2020 Jun;34(11):1499-1504. doi: 10.1080/14786419.2018.1493736.
Shanwen Zhang 1 2,  Chun Gui 1 2,  Mingwei Shao 1 2,  Pachaiyappan Saravana Kumar 1,  Hongbo Huang 1,  Jianhua Ju 1 2
Affiliations

Affiliations

  • 1 CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China.
  • 2 University of Chinese Academy of Sciences, Beijing, China.
PMID: 30445836 DOI: 10.1080/14786419.2018.1493736
Abstract

Tunicamycin E (1), featuring a methyl substitution at C-10', was isolated from marine-derived Streptomyces xinghaiensis SCSIO S15077 originated from the South China Sea sediment together with six known compounds, tunicamycin B (2), tunicamycin X (3), tunicamycin A (4), streptovirudin D2 (5), tunicamycin C (6), and tunicamycin C3 (7). The structure of compound 1 was elucidated by detailed spectroscopic data analyses. All the compounds exhibited strong to moderate Antibacterial activity against Gram-positive bacteria Bacillus thuringiensis BT01 and B. thuringiensis W102 with MIC values ranging from 0.008 to 2 μg/mL. Moreover, compounds 1-7 exhibited moderate Antifungal activity against Candida albicans ATCC 96901 and C. albicans CMCC (F) 98001 with MIC values ranging from 2 to 32 μg/mL. This is the first report that tunicamycins exhibit antimicrobial activities against B. thuringiensis, C. albicans CMCC (F) 98001 and a fluconazole resistant strain C. albicans ATCC 96901.

Keywords

Streptomyces xinghaiensis; Tunicamycin; antimicrobial activity; nucleotide antibiotics.

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