2. Academic Validation
  3. Resveratrol, lunularin and dihydroresveratrol do not act as caloric restriction mimetics when administered intraperitoneally in mice

Resveratrol, lunularin and dihydroresveratrol do not act as caloric restriction mimetics when administered intraperitoneally in mice

  • Sci Rep. 2019 Mar 14;9(1):4445. doi: 10.1038/s41598-019-41050-2.
Kathrin Pallauf 1,  Dawn Chin 2,  Ilka Günther 2,  Marc Birringer 3,  Kai Lüersen 2,  Gerald Schultheiß 4,  Sarah Vieten 4,  Jürgen Krauß 5,  Franz Bracher 5,  Nicolas Danylec 6,  Sebastian T Soukup 6,  Sabine E Kulling 6,  Gerald Rimbach 2
Affiliations

Affiliations

  • 1 Institute of Human Nutrition and Food Science, University of Kiel, Hermann-Rodewald-Straße 6, 24118, Kiel, Germany. [email protected].
  • 2 Institute of Human Nutrition and Food Science, University of Kiel, Hermann-Rodewald-Straße 6, 24118, Kiel, Germany.
  • 3 Department of Nutritional, Food and Consumer Sciences, Fulda University of Applied Sciences, Leipziger Straße 123, 36037, Fulda, Germany.
  • 4 Animal welfare office, University of Kiel, Olshausenstraße 40, 24118, Kiel, Germany.
  • 5 Department of Pharmacy, Center for Drug Research, Ludwig-Maximilians University, Butenandtstraße 5-13, 81377, Munich, Germany.
  • 6 Max Rubner-Institut, Federal Research Institute of Nutrition and Food, Department of Safety and Quality of Fruit and Vegetables, Haid-und-Neu-Straße 9, 76131, Karlsruhe, Germany.
PMID: 30872769 DOI: 10.1038/s41598-019-41050-2
Abstract

Resveratrol as well as caloric restriction were shown to extend lifespan in some model organisms and may possibly delay onset of ageing-related diseases in humans. Yet, resveratrol supplementation does not always extend lifespan of animal models or improve health status of humans. Because of interindividual differences in human microbiota, resveratrol metabolite production in the gut differs. While some individuals produce lunularin and dihydroresveratrol in their gut, Others produce dihydroresveratrol only. Therefore, we addressed the question whether these metabolites differ in their biological impact on ageing and intraperitoneally injected 13-month-old C57BL/6JRj mice on an ad-libitum (AL) HFD with resveratrol, dihydroresveratrol or lunularin (24 mg/kg bodyweight; 3 times/week). Compared to mice injected with vehicle (AL-control), resveratrol and dihydroresveratrol did not change bodyweight and had no impact on Insulin or glucose levels while lunularin slightly reduced feed intake and bodyweight gain. CR-mice showed lowered Cholesterol, Insulin and Leptin levels, elevated Adiponectin and phosphorylated AMPK levels in liver as well as increased transcription of Pck1 and Pgc1α when compared to the AL-control. In contrast, injections with the test substances did not change these parameters. We therefore conclude that in our model, resveratrol, lunularin and dihydroresveratrol did not act as CR mimetics.

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