2. Academic Validation
  3. Cathepsin G and Its Role in Inflammation and Autoimmune Diseases

Cathepsin G and Its Role in Inflammation and Autoimmune Diseases

  • Arch Rheumatol. 2018 Jan 22;33(4):498-504. doi: 10.5606/ArchRheumatol.2018.6595.
Siming Gao 1,  Honglin Zhu 1,  Xiaoxia Zuo 1,  Hui Luo 1
Affiliations

Affiliation

  • 1 Department of Rheumatology, Xiangya Hospital, Hunan, China.
PMID: 30874236 DOI: 10.5606/ArchRheumatol.2018.6595
Abstract

Cathepsin G belongs to the neutrophil serine proteases family, known for its function in killing pathogens. Studies over the past several years indicate that Cathepsin G has important effects on inflammation and immune reaction, and may be a key factor in the pathogenesis of some autoimmune diseases. In this article, we discuss the roles of Cathepsin G in inflammation, immune reaction, and autoimmune diseases. To our knowledge, this is the first study providing important information about Cathepsin G in the pathogenesis of autoimmune diseases and suggesting that Cathepsin G may be a new biomarker or treatment target.

Keywords

Autoimmune disease; cathepsin G; immune reaction; inflammation.

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