2. Academic Validation
  3. Radicicol enhances the regeneration of skeletal muscle injured by crotoxin via decrease of NF-kB activation

Radicicol enhances the regeneration of skeletal muscle injured by crotoxin via decrease of NF-kB activation

  • Toxicon. 2019 Sep;167:6-9. doi: 10.1016/j.toxicon.2019.06.011.
T L Nascimento 1,  T C Conte 1,  T S Rissato 1,  M S Luna 2,  A G Soares 3,  A S Moriscot 1,  N Yamanouye 2,  E H Miyabara 4
Affiliations

Affiliations

  • 1 Department of Anatomy, Biomedical Sciences Institute, University of São Paulo. Av. Lineu Prestes 2415, 05508-000, São Paulo, SP, Brazil.
  • 2 Pharmacology Laboratory, Butantan Institute, Av. Vital Brazil 1500, 05503-900, São Paulo, SP, Brazil.
  • 3 Department of Pharmacology, Biomedical Sciences Institute, University of São Paulo. Av Lineu Prestes 1524, 05508-900, São Paulo, SP, Brazil.
  • 4 Department of Anatomy, Biomedical Sciences Institute, University of São Paulo. Av. Lineu Prestes 2415, 05508-000, São Paulo, SP, Brazil. Electronic address: [email protected].
PMID: 31173791 DOI: 10.1016/j.toxicon.2019.06.011
Abstract

This study evaluated cellular and molecular effects of radicicol, a heat shock protein (HSP) inducer, on the regeneration of skeletal muscle injured by crotoxin, the main toxin isolated from Crotalus durissus terrificus venom. Regenerating muscles treated with radicicol had decreased NF-kB activation. Differentiating myoblasts treated with radicicol showed reduced number of NF-kB positive nuclei and increased fusion index. The results suggest that radicicol enhances regeneration of muscle by attenuating NF-kB activation and increasing myogenic differentiation.

Keywords

Crotoxin; Heat shock proteins; Muscle damage; Nuclear factor kappa B.

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