2. Academic Validation
  3. NNC 55-0396, a T-type calcium channel blocker, protects against the brain injury induced by middle cerebral artery occlusion and reperfusion in mice

NNC 55-0396, a T-type calcium channel blocker, protects against the brain injury induced by middle cerebral artery occlusion and reperfusion in mice

  • J Pharmacol Sci. 2019 Jun;140(2):193-196. doi: 10.1016/j.jphs.2019.02.002.
Sachi Matsuda 1,  Hiroyuki Nishikawa 1,  Anna Fukatsu 1,  Yuko Kurokawa 1,  Maho Tsubota 1,  Fumiko Sekiguchi 1,  Shogo Tokuyama 2,  Atsufumi Kawabata 3
Affiliations

Affiliations

  • 1 Laboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University (formerly Kinki University), Higashi-Osaka 577-8502, Japan.
  • 2 Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Kobe Gakuin University, Kobe 650-8586, Japan.
  • 3 Laboratory of Pharmacology and Pathophysiology, Faculty of Pharmacy, Kindai University (formerly Kinki University), Higashi-Osaka 577-8502, Japan. Electronic address: [email protected].
PMID: 31235271 DOI: 10.1016/j.jphs.2019.02.002
Abstract

We tested whether NNC 55-0396 (NNC), a T-type calcium channel (T-channel) blocker, reduces the brain injury caused by middle cerebral artery occlusion and reperfusion (MCAO/R) in mice. NNC, administered i.c.v. before the occlusion, greatly reduced the MCAO/R-induced brain infarct and neurological dysfunctions, although it, given toward the end of occlusion, was less effective. Systemic administration of NNC before the occlusion also attenuated the infarct and neurological dysfunctions. Our data imply that blood-brain-barrier-permeable T-channel blockers such as NNC are capable of reducing MCAO/R-induced brain damage, and that T-channels are involved in neuronal damage induced by ischemia rather than reperfusion.

Keywords

Ischemia-reperfusion; Middle cerebral artery occlusion; T-type calcium channel.

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