1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. Calcium Channel
  3. NNC 55-0396

NNC 55-0396 (Synonyms: NNC 55-0396 dihydrochloride)

Cat. No.: HY-50722 Purity: 99.24%
Handling Instructions

NNC 55-0396, Mibefradil derivative, is a highly selective T-type calcium channel blocker; displays IC50 values of 6.8 and > 100 μM for inhibition of Cav3.1 T-type channels and HVA currents respectively in INS-1 cells.

For research use only. We do not sell to patients.

NNC 55-0396 Chemical Structure

NNC 55-0396 Chemical Structure

CAS No. : 357400-13-6

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 348 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 348 In-stock
Estimated Time of Arrival: December 31
Solid
1 mg USD 140 In-stock
Estimated Time of Arrival: December 31
5 mg USD 280 In-stock
Estimated Time of Arrival: December 31
10 mg   Get quote  
50 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

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Description

NNC 55-0396, Mibefradil derivative, is a highly selective T-type calcium channel blocker; displays IC50 values of 6.8 and > 100 μM for inhibition of Cav3.1 T-type channels and HVA currents respectively in INS-1 cells. IC50 value: 6.8 nM Target: Cav3.1 T-type channel NNC 55-0396 can be an essential tool in preventing human ovarian cancer cell proliferation as a result of its ability to inhibit the function of T-type Ca2+ channels. It is believed that NNC 55-0396 may functions by dissolving in or passing through the plasma membrane of cells.

Molecular Weight

564.56

Formula

C30H40Cl2FN3O2

CAS No.
SMILES

O=C(C1CC1)O[[email protected]@]2(CCN(CCCC3=NC4=CC=CC=C4N3)C)[[email protected]@H](C(C)C)C5=C(C=C(F)C=C5)CC2.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (177.13 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7713 mL 8.8565 mL 17.7129 mL
5 mM 0.3543 mL 1.7713 mL 3.5426 mL
10 mM 0.1771 mL 0.8856 mL 1.7713 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.68 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.68 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.68 mM); Clear solution

*All of the co-solvents are available by MCE.
References

Purity: 99.24%

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Product Name:
NNC 55-0396
Cat. No.:
HY-50722
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