2. Academic Validation
  3. Endoplasmic reticulum stress mediated the xanthohumol induced murine melanoma B16-F10 cell death

Endoplasmic reticulum stress mediated the xanthohumol induced murine melanoma B16-F10 cell death

  • J Asian Nat Prod Res. 2020 Sep;22(9):850-863. doi: 10.1080/10286020.2019.1644623.
Yi-Ming Zhang 1,  Xiao-Bing Shi 1,  Bo Xu 1,  Cheng-Shan Yuan 2,  Wei Zheng 1,  Gang Li 1,  Ji Li 1,  Zhen-Hua Wang 1
Affiliations

Affiliations

  • 1 Center for Mitochondria and Healthy Ageing, College of Life Sciences, Yantai University, Yantai 264005, China.
  • 2 State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China.
PMID: 31345059 DOI: 10.1080/10286020.2019.1644623
Abstract

Xanthohumol (XN) exerts a specific cytotoxicity in B16-F10 melanoma cells with cytoplasmic vacuoles formation. Further investigation showed XN inhibited cell proliferation in a time- and dose-dependent manner along with down-regulation of mitogen-activated protein kinase and up-regulation of the endoplasmic reticulum (ER) stress marker Bip, CHOP and protein ubiquitination, which was relieved by the ER-stress inhibitor 4-PBA. Whereas no early Apoptosis characteristics was identified during XN induced cell death. [Formula: see text].

Keywords

B16-F10 melanoma cells; endoplasmic reticulum stress; non-apoptosis death; xanthohumol.

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