2. Academic Validation
  3. Lycopodium alkaloids from Huperzia serrata

Lycopodium alkaloids from Huperzia serrata

  • Fitoterapia. 2019 Sep;137:104277. doi: 10.1016/j.fitote.2019.104277.
Fangfang Jiang 1,  Bowen Qi 1,  Ning Ding 1,  Hongyun Yang 1,  Fangfang Jia 1,  Yuan Luo 1,  Juan Wang 1,  Xiao Liu 1,  Xiaohui Wang 1,  Pengfei Tu 1,  Shepo Shi 2
Affiliations

Affiliations

  • 1 Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China.
  • 2 Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China; Beijing Key Lab for Quality Evaluation of Chinese Meteria Medica, Beijing University of Chinese Medicine, Beijing 100029, China. Electronic address: [email protected].
PMID: 31351127 DOI: 10.1016/j.fitote.2019.104277
Abstract

Five new Lycopodium Alkaloids, huperzine Y1 (1), huperzine Y2 (2), huperzine Y3 (3), (+)-huperzine Z (4a) and (-)-huperzine Z (4b) as well as ten known Alkaloids (5-14) were isolated from Huperzia serrata. The structures of the new compounds were established using extensive spectroscopic (1D and 2D NMR, IR, and HRESIMS) and calculated electronic circular dichroism (ECD) methods. Compounds 4a and 4b were a pair of enantiomers successfully separated by chiral HPLC resolution. Compounds 2 and 3 indicated inhibitory activities against acetylcholinesterase with IC50 value of 57.1 ± 1.6 and 32.7 ± 1.0 μΜ, respectively. However, no compound showed inhibitory effect on butyrocholinesterase at the concentration of 100 μΜ.

Keywords

AChE inhibitory activity; BuChE inhibitory activity; Huperzia serrata; Lycopodium alkaloid; Structural determination.

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