2. Academic Validation
  3. Antiviral effects of simeprevir on multiple viruses

Antiviral effects of simeprevir on multiple viruses

  • Antiviral Res. 2019 Dec;172:104607. doi: 10.1016/j.antiviral.2019.104607.
Zheng Li 1,  Fujia Yao 1,  Guang Xue 1,  Yongfen Xu 1,  Junling Niu 1,  Mengmeng Cui 1,  Hongbin Wang 1,  Shuxian Wu 1,  Ailing Lu 2,  Jin Zhong 1,  Guangxun Meng 3
Affiliations

Affiliations

  • 1 CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China; University of Chinese Academy of Sciences, Beijing, 100039, China.
  • 2 CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China; University of Chinese Academy of Sciences, Beijing, 100039, China; Faculty of Medical Laboratory Science, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China.
  • 3 CAS Key Laboratory of Molecular Virology & Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, 200031, China; University of Chinese Academy of Sciences, Beijing, 100039, China. Electronic address: [email protected].
PMID: 31563599 DOI: 10.1016/j.antiviral.2019.104607
Abstract

Simeprevir was developed as a small molecular drug targeting the NS3/4A protease of hepatitis C virus (HCV). Unexpectedly, our current work discovered that Simeprevir effectively promoted the transcription of IFN-β and ISG15, inhibited the Infection of host cells by multiple viruses including Zika virus (ZIKV), Enterovirus A71 (EV-A71), as well as herpes simplex virus type 1 (HSV-1). However, the inhibitory effects of Simeprevir on ZIKV, EV-A71 and HSV-1 were independent from IFN-β and ISG15. This study thus demonstrates that the application of Simeprevir can be extended to other viruses besides HCV.

Keywords

EV-A71; HSV-1; IFN-β; ISG15; Simeprevir; ZIKV.

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