IL-17D: A Less Studied Cytokine of IL-17 Family

Int Arch Allergy Immunol. 2020;181(8):618-623. doi: 10.1159/000508255.

Xuying Liu ¹, Siyu Sun ², Dongyan Liu ³

Affiliations

1 Department of Gastroenterology and Medical Research Center, Liaoning Key Laboratory of Research and Application of Animal Models for Environmental and Metabolic Diseases, Sheng Jing Hospital of China Medical University, ShenYang, China.
2 Department of Gastroenterology, ShengJing Hospital of China Medical University, ShenYang, China.
3 Department of Gastroenterology and Medical Research Center, Liaoning Key Laboratory of Research and Application of Animal Models for Environmental and Metabolic Diseases, Sheng Jing Hospital of China Medical University, ShenYang, China, [email protected].

Abstract

The interleukin-17 (IL-17) family is a relatively new family of cytokines consisting of 6 related factors (IL-17A-IL-17F), while the receptor family consists of 5 members: IL-17RA-IL-17RE. IL-17A is the prototype member of this family, which is also the signature cytokine of T helper 17 (Th17) cells. Th17 cells are involved in the development of autoimmune disease, inflammation, and tumors. Although IL-17D is similar to IL-17A in its ability to induce inflammatory cytokine production, there are fewer studies on IL-17D. Recently, the role of IL-17D in tumors and infections has attracted our attention. Some knowledge of function of IL-17D has been gained by studies using nonmammalian species. In this review, we introduce the structural characteristics, expression patterns, and biological characteristics of IL-17D along with its potential function in the pathogenesis of disease.

Keywords

Cytokine; IL-17D; Infection; Inflammation; Tumor.

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