IL-17D

Interleukin-17D (IL-17D) belongs to the IL-17 cytokine family. IL-17D is highly secreted by fibrosarcoma tumor cells^[1]. IL-17D is highly expressed in skeletal muscle, brain, adipose tissue, heart, lung, and pancreas, while it is expressed at low levels in bone marrow, fetal liver, kidney, leukocytes, liver, lymph nodes, placenta, spleen, thymus, and tonsils^[2]. IL-17D stimulates the production of IL-6, IL-8, and GM-CSF. IL-17D also induces myeloid growth factors and chemokines. IL-17D stimulates local infiltration and proliferation of leukocytes^[2]. IL-17D regulates protective immunity during intracellular bacteria and virus infection via regulating CD8 T cells^[1]. IL-17D plays multiple roles in autoimmune disease and is a potential target for tumor immunotherapy^[2].

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