2. Academic Validation
  3. Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity

Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity

  • Cell Rep. 2021 Jan 5;34(1):108601. doi: 10.1016/j.celrep.2020.108601.
Xian Zhou 1,  Xingxing Zhu 1,  Chaofan Li 2,  Yanfeng Li 1,  Zhenqing Ye 3,  Virginia Smith Shapiro 4,  John A Copland 3rd 5,  Taro Hitosugi 6,  David A Bernlohr 7,  Jie Sun 8,  Hu Zeng 9
Affiliations

Affiliations

  • 1 Division of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
  • 2 Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.
  • 3 Department of Biostatistics and Informatics, Mayo Clinic, Rochester, MN 55905, USA.
  • 4 Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.
  • 5 Department of Cancer Biology, Mayo Clinic, Jacksonville, FL 32224, USA.
  • 6 Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA.
  • 7 Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.
  • 8 Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA; Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA.
  • 9 Division of Rheumatology, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA; Department of Immunology, Mayo Clinic, Rochester, MN 55905, USA. Electronic address: [email protected].
PMID: 33406440 DOI: 10.1016/j.celrep.2020.108601
Abstract

Immune cells can metabolize glucose, Amino acids, and fatty acids (FAs) to generate energy. The roles of different FA species and their impacts on humoral immunity remain poorly understood. Here, we report that proliferating B cells require monounsaturated FAs (MUFAs) to maintain Mitochondrial Metabolism and mTOR activity and to prevent excessive Autophagy and endoplasmic reticulum (ER) stress. Furthermore, B cell-extrinsic stearoyl-CoA desaturase (SCD) activity generates MUFA to support early B cell development and germinal center (GC) formation in vivo during immunization and influenza Infection. Thus, SCD-mediated MUFA production is critical for humoral immunity.

Keywords

B cell; autophagy; humoral immunity; mTOR; monounsaturated fatty acid; stearoyl-CoA desaturase.

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