2. Academic Validation
  3. Structure and regulation of human phospholipase D

Structure and regulation of human phospholipase D

  • Adv Biol Regul. 2021 Jan:79:100783. doi: 10.1016/j.jbior.2020.100783.
Forrest Z Bowling 1,  Michael A Frohman 2,  Michael V Airola 3
Affiliations

Affiliations

  • 1 Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY, USA.
  • 2 Department of Pharmacological Sciences, Stony Brook University, Stony Brook, NY, USA.
  • 3 Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY, USA. Electronic address: [email protected].
PMID: 33495125 DOI: 10.1016/j.jbior.2020.100783
Abstract

Mammalian Phospholipase D (PLD) generates phosphatidic acid, a dynamic lipid secondary messenger involved with a broad spectrum of cellular functions including but not limited to metabolism, migration, and exocytosis. As a promising pharmaceutical target, the biochemical properties of PLD have been well characterized. This has led to the recent crystal structures of human PLD1 and PLD2, the development of PLD specific pharmacological inhibitors, and the identification of cellular regulators of PLD. In this review, we discuss the PLD1 and PLD2 structures, PLD inhibition by small molecules, and the regulation of PLD activity by effector proteins and lipids.

Keywords

Cancer; Cell signaling; Phosphatidic acid; Phospholipase D; Protein structure.

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