2. Academic Validation
  3. Toxicological Effects of BPDE on Dysfunctions of Female Trophoblast Cells

Toxicological Effects of BPDE on Dysfunctions of Female Trophoblast Cells

  • Adv Exp Med Biol. 2021:1300:151-160. doi: 10.1007/978-981-33-4187-6_7.
Rong Wang 1,  Xinying Huang 1,  Chenglong Ma 1,  Huidong Zhang 2
Affiliations

Affiliations

  • 1 Key Laboratory of Environment and Female Reproductive Health, West China School of Public Health, Sichuan University, Chengdu, China.
  • 2 Key Laboratory of Environment and Female Reproductive Health, West China School of Public Health, Sichuan University, Chengdu, China. [email protected].
PMID: 33523433 DOI: 10.1007/978-981-33-4187-6_7
Abstract

Polycyclic aromatic hydrocarbons (PAHs) are widely spread persistent environmental toxicants. Its typical representative benzo[a]pyrene (BaP) is a human carcinogen. BaP can pass through the placental barrier and is finally metabolized into benzo[a]pyren-7, 8-dihydrodiol-9, 10-epoxide (BPDE). BPDE can form DNA adducts, which directly affect the female reproductive health. Based on the special physiological functions of trophoblast cells and its important effect on normal pregnancy, this chapter describes the toxicity and molecular mechanism of BPDE-induced dysfunctions of trophoblast cells. By affecting the invasion, migration, Apoptosis, proliferation, inflammation, and hormone secretion of trophoblast cells, BPDE causes diseases such as choriocarcinoma, intrauterine growth restriction, eclampsia, and abortion. In the end, it is expected to provide a scientific basis and prevention approach for women's reproductive health and decision-making basis for the formulation of environmental health standards.

Keywords

Apoptosis; BaP/BPDE; Cell cycle; Hormone secretion; Inflammatory cytokines; Invasion and migration; Trophoblast cell.

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