Benzo[a]pyrene diol epoxide
Benzo[a]pyrene diol epoxide is a carcinogen present in tobacco smoke as well as in environmental pollution. Benzo[a]pyrene diol epoxide is a metabolite of benzo[a]pyrene (BaP) , which is polycyclic aromatic hydrocarbon (PAH) . Benzo[a]pyrene diol epoxide induces esophageal carcinogenesis. Benzo[a]pyrene diol epoxide may act to induce activation of ERKs and p38 MAPK marked by an increased level of phosphorylation of both the ERKs and p38 MAPK which corresponds with the increased activation of both kinases as evidenced by increased phsosphorylation of their substrates Elk-1 and ATF-2, respectively.
For research use only. We do not sell to patients.
- CAS No.: 58917-67-2
- Formula: C20H14O3
- Molecular Weight:302.32
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Storage:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
![Benzo[a]pyrene diol epoxide Chemical Structure](https://file.medchemexpress.com/product_pic/hy-w585976.gif "Click to View Benzo[a]pyrene diol epoxide Chemical Structure")
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 58917-67-2
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Appearance Solid
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Molecular Weight 302.32
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Formula C20H14O3
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Color Light yellow to yellow
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SMILES
O[C@@H]1C2=C([C@]3([H])[C@@]([C@H]1O)([H])O3)C4=C5C6=C(C=CC5=C2)C=CC=C6C=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Hussain SP, Amstad P, Raja K, et al. Mutability of p53 hotspot codons to benzo(a)pyrene diol epoxide (BPDE) and the frequency of p53 mutations in nontumorous human lung. Cancer Res. 2001;61(17):6350-6355. [Content Brief]
[2]. Huang X, Ma C, Huang W, et al. Environmental BPDE induced human trophoblast cell apoptosis by up-regulating lnc-HZ01/p53 positive feedback loop. Ecotoxicol Environ Saf. 2022;237:113564. [Content Brief]
[3]. Wang R, Huang X, Ma C, Zhang H. Toxicological Effects of BPDE on Dysfunctions of Female Trophoblast Cells. Adv Exp Med Biol. 2021;1300:151-160. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Benzo[a]pyrene diol epoxide Related Classifications
HY-W585976 Related Classifications
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