2. Academic Validation
  3. Comparative effects of genistein and bisphenol A on non-alcoholic fatty liver disease in laying hens

Comparative effects of genistein and bisphenol A on non-alcoholic fatty liver disease in laying hens

  • Environ Pollut. 2021 Nov 1;288:117795. doi: 10.1016/j.envpol.2021.117795.
Xiaona Gao 1,  Shuhui Liu 1,  Chenchen Ding 1,  Yufan Miao 1,  Zhangshan Gao 1,  Mengcong Li 1,  Wentao Fan 1,  Zhihui Tang 1,  Nobuhle Hyacinth Mhlambi 1,  Liping Yan 2,  Suquan Song 3
Affiliations

Affiliations

  • 1 MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China.
  • 2 MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China; Jiangsu Engineering Laboratory of Animal Immunology, Jiangsu Detection Center of Terrestrial Wildlife Disease, Institute of Immunology, Nanjing Agricultural University, Nanjing, Jiangsu, China.
  • 3 MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, 210095, Jiangsu Province, China. Electronic address: [email protected].
PMID: 34274649 DOI: 10.1016/j.envpol.2021.117795
Abstract

Bisphenol A (BPA) and genistein (GEN) are selective Estrogen Receptor modulators, which are involved in the occurrence and development of metabolic syndrome. However, their roles in non-alcoholic fatty liver disease (NAFLD) of laying hens have not been reported. Here, we investigated the effects of different concentrations of GEN and BPA on the NAFLD of laying hens. Results showed that GEN ameliorated the high-energy and low-protein diet (HELP)-induced NAFLD by improving pathological damage, hepatic steatosis, and Insulin resistance and blocking the expression of NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome-related factors. By contrast, high dose of BPA could aggravate these changes with serious symptom of NAFLD and suppress the level of ERα in the liver considerably, while GEN could reverse this phenomenon in a dose-dependent manner. In general, our research shows that the protective effect of GEN on NAFLD aims to improve the metabolic disorders and inflammation closely connected to ERα, while BPA can inhibit the expression of ERα and exacerbate the symptom of NAFLD. In conclusion, we elucidate the opposing effects of GEN and BPA in NAFLD of laying hens, thus providing a potential mechanism related to ERα and inflammation.

Keywords

Bisphenol A; ERα; Genistein; Inflammation; NAFLD.

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