2. Academic Validation
  3. The anticancer activity of carbazole alkaloids

The anticancer activity of carbazole alkaloids

  • Arch Pharm (Weinheim). 2022 Jan;355(1):e2100277. doi: 10.1002/ardp.202100277.
Feng Song 1,  Dan Liu 2,  Xiankai Huo 3,  Di Qiu 4
Affiliations

Affiliations

  • 1 Shandong Key Laboratory of Biophysics, Institute of Biophysics, Dezhou University, Dezhou, Shandong, China.
  • 2 Dezhou Number One Middle School, Dezhou, Shandong, China.
  • 3 Department of Medical Imaging, Dezhou People's Hospital, Dezhou, Shandong, China.
  • 4 Department of Hematology, Zhuji Affiliated Hospital of Shaoxing University, Shaoxing, Zhejiang, China.
PMID: 34486161 DOI: 10.1002/ardp.202100277
Abstract

Chemotherapy is the first choice for the majority of cancers, but severe side effects and drug resistance restrict the actual clinical efficacy. Carbazole Alkaloids, mainly from the Rutaceae family, possess favorable donor ability, good planarity, rich photophysical properties, and excellent biocompatibility. Carbazole Alkaloids could not only intercalate in DNA but could also inhibit Telomerase and Topoisomerase and regulate protein phosphorylation. Hence, carbazole Alkaloids are useful in providing lead hits/candidates for the development of novel Anticancer agents. This review summarizes the research progress made regarding the Anticancer properties of carbazole Alkaloids, covering articles published from January 2010 to June 2021.

Keywords

anticancer; carbazole alkaloids; mechanism of action; nature-derived compounds.

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