7-Oxostaurosporine
7-Oxostaurosporine is a potent protein kinase C (PKC) inhibitor that effectively inhibits tumor growth by inducing apoptosis and inhibiting the nuclear factor (NF)-κB/p-p65 pathway.
For research use only. We do not sell to patients.
- CAS No.: 125035-83-8
- Formula: C28H24N4O4
- Molecular Weight:480.51
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.78 μM
Compound: 15
|
Cytotoxicity in human A549 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
Cytotoxicity in human A549 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
|
[PMID: 33100009] |
| ASPC1 | IC50 |
1.2 μM
Compound: 15
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Cytotoxicity in human ASPC1 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
Cytotoxicity in human ASPC1 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
|
[PMID: 33100009] |
| BXPC-3 | IC50 |
0.43 μM
Compound: 15
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Cytotoxicity in human BXPC-3 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
Cytotoxicity in human BXPC-3 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
|
[PMID: 33100009] |
| MGC-803 | IC50 |
1.52 μM
Compound: 15
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Cytotoxicity in human MGC-803 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
Cytotoxicity in human MGC-803 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
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[PMID: 33100009] |
| NCI-H1299 | IC50 |
2.03 μM
Compound: 15
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Cytotoxicity in human NCI-H1299 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
Cytotoxicity in human NCI-H1299 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
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[PMID: 33100009] |
| NCI-H1975 | IC50 |
2.01 μM
Compound: 15
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Cytotoxicity in human NCI-H1975 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
Cytotoxicity in human NCI-H1975 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
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[PMID: 33100009] |
| PC-9 | IC50 |
1.88 μM
Compound: 15
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Cytotoxicity in human PC-9 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
Cytotoxicity in human PC-9 cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
|
[PMID: 33100009] |
| RKO | IC50 |
1.47 μM
Compound: 15
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Cytotoxicity in human RKO cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
Cytotoxicity in human RKO cells assessed as reduction in cell viability incubated for 24 hrs by CCK8 assay
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[PMID: 33100009] |
7-Oxostaurosporine (50 nM, 24 h) can lead to an increase in plasma membrane sphingomyelin in CHO cells but does not alter ceramide content[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 125035-83-8
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Molecular Weight 480.51
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Formula C28H24N4O4
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SMILES
[H][C@@]12N3C4=C(C5=C(C6=C4C7=C3C=CC=C7)C(NC6=O)=O)N(C8=C5C=CC=C8)[C@](C)([C@@H]([C@@H](C2)NC)OC)O1
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Synonyms
BMY-41950
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Masashi Maekawa, et al. Staurosporines decrease ORMDL proteins and enhance sphingomyelin synthesis resulting in depletion of plasmalemmal phosphatidylserine. Sci Rep. 2016 Nov 2;6:35762. [Content Brief]
[2]. Feng Song, et al. The anticancer activity of carbazole alkaloids. Arch Pharm (Weinheim). 2022 Jan;355(1):e2100277. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
7-Oxostaurosporine Related Classifications
HY-120515 Related Classifications
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