Siccanin
Siccanin is a succinate dehydrogenase (SDH) inhibitor (IC50=0.9 μM) with species-selective activity. Siccanin also is a antibiotic against pathogenic fungi.
For research use only. We do not sell to patients.
- CAS No.: 22733-60-4
- Formula: C22H30O3
- Molecular Weight:342.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
IC50 & Target
Succinate Dehydrogenase Inhibitor
In Vitro
Siccanin (10 μg/mL) is species-selective, and Siccanin inhibits bacterial SDH from P. aeruginosa and P. putida but not SDH from E. coli, and C. glutamicum; Siccanin inhibits rodent SDH but not porcine SDH[1].
Specifically, Siccanin inhibits SDH from P. aeruginosa (residual activity 13%) and P. putida (>1%) membranes, and of mouse (>7%) and rat (19%) liver mitochondria, but not SDH from E. coli (77%) and C. glutamicum (97%) membranes and of porcine heart mitochondria (106%)[1].
Siccanin (3 μg/mL) competely inhibits the growth of Trichophyton mentagrophytes (IC50=0.3 μg/mL)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 22733-60-4
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Molecular Weight 342.47
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Formula C22H30O3
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SMILES
C[C@@]12[C@@]3([H])[C@@]4(CO[C@@]3([H])C5=C(O)C=C(C)C=C5O2)[C@@](C(C)(CCC4)C)([H])CC1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Siccanin Related Classifications
HY-106371 Related Classifications
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