15-deoxy-Δ12,14-Prostaglandin D2
Based on 1 Customer Validation
15-deoxy-Δ12,14-Prostaglandin D2 (15-Deoxy-Δ12,14-PGD2) is a metabolite of prostaglandin D₂ (PGD₂) (HY-101988), which can undergo further dehydration metabolism to 15-deoxy-Δ12,14-PGJ₂. 15-deoxy-Δ12,14-Prostaglandin D2 is a highly selective agonist for DP2 receptor and PPARγ. 15-deoxy-Δ12,14-Prostaglandin D2 causes morphological changes in eosinophils and migration of type II innate lymphoid cells (ILC2). 15-deoxy-Δ12,14-Prostaglandin D2 has a growth inhibitory effect on prostate cancer cells expressing PPARγ, induces cell cycle arrest and promotes apoptosis. 15-deoxy-Δ12,14-Prostaglandin D2 can be used in related research on asthma and prostate cancer.
For research use only. We do not sell to patients.
- Purity : 98.0%
- CAS No.: 85235-11-6
- Formula: C20H30O4
- Molecular Weight:334.45
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Storage:
Solution, -20°C, 2 years
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Description
In Vitro
15-deoxy-Δ12,14-Prostaglandin D2 (0.01 nM-1 µM; 5 min) induces morphological changes in eosinophils isolated from patients with atopic asthma, with a mean EC50 of 1.5 nM, and produces a maximum response similar to that of PGD2[1].
15-deoxy-Δ12,14-Prostaglandin D2 (5 nM-5 µM; 6 h) induces migration of ILC2, with a mean EC50 value of 21.8 nM, and elicits a stronger maximal migratory response than PGD2[1].
15-deoxy-Δ12,14-Prostaglandin D2 (2.5 nM-2.5 µM; 24 h) induces IL-5 and IL-13 secretion by ILC2, with mean EC50 values of 175.4 nM and 159.1 nM, respectively. The maximum cytokine response level is similar to that of PGD2[1].
15-deoxy-Δ12,14-Prostaglandin D2 (1-10 μM; 72 h) inhibits the growth of PC-3 prostate cancer cells in a concentration-dependent manner within 72 hours[2].
15-deoxy-Δ12,14-Prostaglandin D2 (2 h) can be converted from arachidonic acid by normal prostate stromal cells, and its production level is lower than that of PGD2[2] after incubation with 10 μM arachidonic acid for 2 h.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC-3 prostate cancer cells
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Concentration:1, 5 and 10 μM
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Incubation Time:72 hours
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Result:Caused a concentration- and time-dependent reduction in viable PC-3 cell number, with increased DAPI incorporation into cell nuclei indicating cell death; showed greater growth-suppressive effectiveness than PGD2 but less than 15-deoxy-Δ12,14-prostaglandin J2.
Chemical Information
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CAS No. 85235-11-6
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Appearance Liquid
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Molecular Weight 334.45
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Formula C20H30O4
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Color Colorless to light yellow
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SMILES
O=C1/C([C@H]([C@H](C1)O)C/C=C\CCCC(O)=O)=C/C=C/CCCCC
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Synonyms
15-Deoxy-Δ12,14-PGD2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Solution, -20°C, 2 years
Purity & Documentation
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Data Sheet (286 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
15-deoxy-Δ12,14-Prostaglandin D2 Related Classifications
HY-116028 Related Classifications
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