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15-deoxy-Δ12,14-Prostaglandin D2

(Synonyms: 15-Deoxy-Δ12,14-PGD2)
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15-deoxy-Δ12,14-Prostaglandin D2 (15-Deoxy-Δ12,14-PGD2), a metabolite of PGD2 (HY-101988), is an agonist of prostaglandin receptor 2 (DP2). 15-deoxy-Δ12,14-Prostaglandin D2 binds to DP2 (Ki=50 nM) and induces eosinophil activation (EC50=8 nM). 15-deoxy-Δ12,14-Prostaglandin D2 also stimulates the recruitment of steroid receptor coactivator-1 (SRC-1) to peroxisome proliferator-activated receptor γ (PPARγ), inducing PPARγ-mediated transcription. 15-deoxy-Δ12,14-Prostaglandin D2 (15-Deoxy-Δ12,14-PGD2) is cytotoxic to L1210 murine leukemia cells (IC50=0.3 μg/ml) and inhibits ADP-induced platelet aggregation (IC50=320 ng/mL).

For research use only. We do not sell to patients.

  • Purity: 98.0%
  • CAS No.: 85235-11-6
  • Formula: C20H30O4
  • Molecular Weight:334.45
  • Storage:

    Solution, -20°C, 2 years

  • 15-deoxy-Δ12,14-Prostaglandin D2 Chemical Structure
    15-deoxy-Δ12,14-Prostaglandin D2 Chemical Structure
CAS No.: 85235-11-6
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All Endogenous Metabolite Isoforms

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    15-deoxy-Δ12,14-Prostaglandin D2 Chemical Structure
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  • 15-deoxy-Δ12,14-Prostaglandin D2