DP1

By Targets:	5-HT Receptor (2) Drug Metabolite (1) Isotope-Labeled Compounds (3) Prostaglandin Receptor (10)
By Research Areas:	Cancer (2) Cardiovascular Disease (2) Endocrinology (8) Inflammation/Immunology (9) Neurological Disease (2)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-132995

*DP-1*	Drug Metabolite	Others
DP-1, a degradation product of SDC-TRAP-0063, is a fragment of Ganetespib. Ganetespib is a heat shock protein 90 (HSP90) inhibitor with anti-tumor activity ^[1].

HY-111271A

L 888607 Racemate	Prostaglandin Receptor	Inflammation/Immunology Endocrinology
L 888607 Racemate is a selective prostaglandin D₂ receptor subtype 1 *(DP1)* antagonist, with K_is of 132 nM and 17 nM for DP1 and thromboxane A2 receptor (TP), respectively.

HY-16763

Asapiprant 1 Publications Verification S-555739	Prostaglandin Receptor	Inflammation/Immunology Endocrinology
Asapiprant is a potent and selective DP₁ receptor antagonist with a K_i of 0.44 nM.

HY-101987

BW 245C

Prostaglandin Receptor Cardiovascular Disease Endocrinology

BW 245C is a prostanoid DP-receptor (DP1) agonist, used to treat stroke.

BW 245C	Prostaglandin Receptor	Cardiovascular Disease Endocrinology
BW 245C is a prostanoid DP-receptor (DP1) agonist, used to treat stroke.

HY-16504

Treprostinil sodium 1 Publications Verification UT-15 sodium	Prostaglandin Receptor	Inflammation/Immunology Endocrinology
Treprostinil (UT-15) sodium is a potent *DP1* and EP2 agonist with EC₅₀ values of 0.6±0.1 and 6.2±1.2 nM, respectively.

HY-100441

Treprostinil 1 Publications Verification UT-15	Prostaglandin Receptor	Inflammation/Immunology Endocrinology
Treprostinil (UT-15) is a potent *DP1* and EP2 agonist with EC₅₀ values of 0.6±0.1 and 6.2±1.2 nM, respectively.

HY-16751

Ralinepag APD811	Prostaglandin Receptor	Cardiovascular Disease Endocrinology
Ralinepag is a potent, orally bioavailable and non-prostanoid prostacyclin (IP) receptor agonist, with EC₅₀s of 8.5 nM, 530 nM and 850 nM for human and rat IP receptor and human DP1 receptor, respectively.

HY-18971

TG4-155 1 Publications Verification
TG4-155 is a potent, brain-permeant and selective EP2 receptor antagonist with a K_i of 9.9 nM ^[1] . TG4-155 shows low nanomolar antagonist activity against only EP2 and DP1 ^[1]. TG4-155 has an EP2 Schild K_B of 2.4 nM and displays 550-4750-fold selectivity for EP2 over EP1, EP3, EP4 and IP, but only 14-fold selectivity against the DP1 receptor .

HY-B0813

Treprostinil diethanolamine UT-15C
Treprostinil (UT-15C) diethanolamine is a potent EP2, *DP1* and IP agonist with K_i values of 3.6, 4.4, 32.1, 212, 826, 2505 and 4680 nM for EP2, DP1, IP, EP1, EP4, EP3 and FP, respectively. Treprostinil (UT-15C) diethanolamine increases upregulation of cAMP toward maintaining homeostasis within the vasculature. Treprostinil (UT-15C) diethanolamine can result in vasodilatation of human pulmonary arteries ^[1] .

HY-100441S1

Treprostinil-13C2,d1 UT-15-¹³C₂,d₁	Isotope-Labeled Compounds Prostaglandin Receptor	Inflammation/Immunology Endocrinology
Treprostinil- ¹³C₂,d is the ¹³C- and deuterium labeled Treprostinil. Treprostinil (UT-15) is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.

HY-14973

Vidupiprant AMG 853	Prostaglandin Receptor	Inflammation/Immunology
Vidupiprant (AMG 853) is a phenylacetic acid derivative. Vidupiprant is a potent and orally active CRTH2 (DP2) and prostanoid D receptor (DP or DP1) dual antagonist with IC₅₀s of 3 nM and 4 nM in buffer, and 8 nM and 35 nM in human plasma, respectively. Vidupiprant has the potential for asthma treatment ^[1].

HY-109163

Treprostinil palmitil INS-1009	Prostaglandin Receptor	Inflammation/Immunology Endocrinology
Treprostinil palmitil (TP) is the proagent of *DP1* and EP2 agonist, Treprostinil (UT-15), whose EC₅₀ values were 0.6 and 6.2 nM, respectively. Treprostinil palmitil is a pure proagent and possesses no inherent binding to G-protein coupled receptors including prostanoid receptors ^[1] .

HY-100441S2

Treprostinil-d9 UT-15-d₉	Isotope-Labeled Compounds	Inflammation/Immunology
Treprostinil-d₉ (UT-15-d₉) is the deuterium-labeled Treprostinil (HY-100441) ^[1]. Treprostinil (UT-15) is a potent *DP1* and EP2 agonist with EC₅₀ values of 0.6±0.1 and 6.2±1.2 nM, respectively.

HY-100441S3

Treprostinil-d7 UT-15-d₇	Isotope-Labeled Compounds Prostaglandin Receptor	Inflammation/Immunology
Treprostinil-d7 (UT-15-d7) is a deuterated version of Treprostinil (HY-100441). Treprostinil is a highly potent DP1 and EP2 agonist with EC50s of 0.6 nM and 6.2 nM, respectively ^[1] .

HY-A0095

Flibanserin 2 Publications Verification BIMT-17; BIMT-17BS	5-HT Receptor	Neurological Disease Cancer
Flibanserin (BIMT-17; BIMT-17BS) is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist with K_i values of 1 nM and 49 nM, respectively. Flibanserin binds to dopamine D4 receptors with an K_i value of 4-24 nM. Flibanserin shows anti-depression and anti-anxiety effect, can be used to hypoactive sexual desire disorder (HSDD) research ^[1] ^- .

HY-A0095A

Flibanserin hydrochloride BIMT-17 hydrochloride; BIMT-17BS hydrochloride	5-HT Receptor	Neurological Disease Cancer
Flibanserin (BIMT-17; BIMT-17BS) hydrochloride is an orally active serotonin 5-HT1A receptor agonist and 5-HT2A receptor antagonist with K_i values of 1 nM and 49 nM, respectively. Flibanserin hydrochloride binds to dopamine D4 receptors with an K_i value of 4-24 nM. Flibanserin hydrochloride shows anti-depression and anti-anxiety effect, can be used to hypoactive sexual desire disorder (HSDD) research ^[1] ^- .

Species:	Human (2)
Tag:	His (2)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source

HY-P71696

	HLA-DPB1 Protein, Human (His) HLA class II histocompatibility antigen; HLA class II histocompatibility antigen; DP beta 1 chain; HLA class II histocompatibility antigen; HLA-DP1B; HLA-DPB	Human	E. coli
	The HLA-DPB1 protein is an integral part of the immune system, binding antigens in the endocytic pathway of antigen-presenting cells (APCs). It presents the peptide on the cell surface for recognition by CD4 T cells. HLA-DPB1 Protein, Human (His) is the recombinant human-derived HLA-DPB1 protein, expressed by E. coli , with N-His labeled tag. The total length of HLA-DPB1 Protein, Human (His) is 194 a.a., with molecular weight of ~26.8 kDa.

HY-P71697

	HLA-DPA1 Protein, Human (His) HLA-DPA1; HLA-DP1A; HLASBHLA class II histocompatibility antigen; DP alpha 1 chain; HLA-SB alpha chain; MHC class II DP3-alpha; MHC class II DPA1	Human	E. coli
	The HLA-DPA1 protein is critical in the immune system, binding antigens in the endocytic pathway of APCs and presenting them to the cell surface for recognition by CD4 T cells. The peptide binding cleft can accommodate peptides of 10-30 residues, mainly resulting from protein degradation. HLA-DPA1 Protein, Human (His) is the recombinant human-derived HLA-DPA1 protein, expressed by E. coli , with N-His labeled tag. The total length of HLA-DPA1 Protein, Human (His) is 194 a.a., with molecular weight of ~26.3 kDa.


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Cat. No.	Product Name	Chemical Structure

HY-100441S1

Treprostinil-13C2,d1
Treprostinil- ¹³C₂,d is the ¹³C- and deuterium labeled Treprostinil. Treprostinil (UT-15) is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.

HY-100441S2

Treprostinil-d9
Treprostinil-d₉ (UT-15-d₉) is the deuterium-labeled Treprostinil (HY-100441) ^[1]. Treprostinil (UT-15) is a potent *DP1* and EP2 agonist with EC₅₀ values of 0.6±0.1 and 6.2±1.2 nM, respectively.

HY-100441S3

Treprostinil-d7
Treprostinil-d7 (UT-15-d7) is a deuterated version of Treprostinil (HY-100441). Treprostinil is a highly potent DP1 and EP2 agonist with EC50s of 0.6 nM and 6.2 nM, respectively ^[1] .

Cat. No.	Product Name	Application	Reactivity

HY-P83021

DP1 Antibody (YA2766)

TFDP1; DP1; Transcription factor DP-1; DRTF1-polypeptide 1; DRTF1; E2F dimerization partner 1
WB, FC Human, Mouse, Rat
HY-P81436

HLA-DP Antibody (YA1181)

HLA DPA1; major histocompatibility complex; class II; DP alpha 1; PLT1; HLADP; HLASB; DP(W3); DP(W4); HLA-DP1A
IHC-P Human

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