2. Academic Validation
  3. In Silico Structure-Based Design of Antiviral Peptides Targeting the Severe Fever with Thrombocytopenia Syndrome Virus Glycoprotein Gn

In Silico Structure-Based Design of Antiviral Peptides Targeting the Severe Fever with Thrombocytopenia Syndrome Virus Glycoprotein Gn

  • Viruses. 2021 Oct 11;13(10):2047. doi: 10.3390/v13102047.
Shuo-Feng Yuan 1,  Lei Wen 1,  Kenn Ka-Heng Chik 1,  Jiang Du 2 3 4 5,  Zi-Wei Ye 1,  Jian-Li Cao 1,  Kai-Ming Tang 1,  Rong-Hui Liang 1,  Jian-Piao Cai 1,  Cui-Ting Luo 1,  Fei-Fei Yin 2 3 4 5,  Gang Lu 2 3 4 5,  Hin Chu 1,  Mi-Fang Liang 6,  Dong-Yan Jin 7,  Kwok-Yung Yuen 1 3 4 5,  Jasper Fuk-Woo Chan 1 3 4 5
Affiliations

Affiliations

  • 1 State Key Laboratory of Emerging Infectious Diseases, Carol Yu Centre for Infection, Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
  • 2 Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Medical University, Haikou 571199, China.
  • 3 Academician Workstation of Hainan Province, Hainan Medical University, Haikou 571199, China.
  • 4 Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Hainan Medical University, Haikou 571101, China.
  • 5 Hainan Medical University-The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, The University of Hong Kong, Pokfulam, Hong Kong, China.
  • 6 Key Laboratory for Medical Virology and National Institute for Viral Disease Control and Prevention, Chinese Centre for Disease Control and Prevention, Beijing 102206, China.
  • 7 School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, China.
PMID: 34696477 DOI: 10.3390/v13102047
Abstract

Severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging tick-borne bunyavirus in Asia that causes severe disease. Despite its clinical importance, treatment options for SFTSV Infection remains limited. The SFTSV glycoprotein Gn plays a major role in mediating virus entry into host cells and is therefore a potential Antiviral target. In this study, we employed an in silico structure-based strategy to design novel cyclic Antiviral peptides that target the SFTSV glycoprotein Gn. Among the cyclic peptides, HKU-P1 potently neutralizes the SFTSV virion. Combinatorial treatment with HKU-P1 and the broad-spectrum viral RNA-dependent RNA polymerase inhibitor favipiravir exhibited synergistic Antiviral effects in vitro. The in silico peptide design platform in this study may facilitate the generation of novel Antiviral peptides for Other emerging viruses.

Keywords

SFSTV; antiviral; bunyavirales; peptide; tick; treatment.

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