2. Academic Validation
  3. GPNMB plays an active role in the M1/M2 balance

GPNMB plays an active role in the M1/M2 balance

  • Tissue Cell. 2022 Feb;74:101683. doi: 10.1016/j.tice.2021.101683.
Hengfang Zhang 1,  Shuang Zhang 2,  Xuan Dang 1,  Lexun Lin 3,  Liping Ren 1,  Rong Song 4
Affiliations

Affiliations

  • 1 First Affiliated Hospital of Harbin Medical University, College of Stomatology, Harbin Medical University, No. 143 Yiman Street, Nangang District, Harbin, 150001, China.
  • 2 Office of International Exchange and Cooperation, Harbin Medical University, No. 157 Baojian Street, Nangang District, Harbin, 150081, China.
  • 3 Department of Pathogenic Microbiology, School of Basic Medical Sciences, Harbin Medical University, No. 157 Baojian Street, Nangang District, Harbin, 150081, China.
  • 4 First Affiliated Hospital of Harbin Medical University, College of Stomatology, Harbin Medical University, No. 143 Yiman Street, Nangang District, Harbin, 150001, China. Electronic address: [email protected].
PMID: 34800878 DOI: 10.1016/j.tice.2021.101683
Abstract

The phenotypic function of macrophages varies with the local microenvironment. Macrophages play an important role in the development of periodontitis. As one of the sources of GPNMB protein, the phenotype of macrophages is affected by GPNMB expression. In this study, activated macrophages were evaluated by flow cytometry, RT-qPCR and WB, and M2a macrophages had higher GPNMB expression than M0 and M1 macrophages. On this basis, a macrophage model with overexpression of GPNMB was established, and it was observed that GPNMB overexpression promoted the secretion of anti-inflammatory factors by macrophages and inhibited the secretion of pro-inflammatory factors by M1 macrophages.

Keywords

Anti-inflammatory; GPNMB; M1 macrophages; M2a macrophages.

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