1. Academic Validation
  2. Letrozole promotes the expression of integrin αvβ3 and HOXA10 in endometrium of endometriosis

Letrozole promotes the expression of integrin αvβ3 and HOXA10 in endometrium of endometriosis

  • Syst Biol Reprod Med. 2022 Apr;68(2):121-128. doi: 10.1080/19396368.2021.2013577.
Jing Zhang 1 Lihui Wang 1 Chunyan Li 1 Hui Zhang 1 Rui Li 1 Mingjiang Li 1
Affiliations

Affiliation

  • 1 Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China.
Abstract

Endometriosis is a common estrogen-dependent chronic inflammatory disease that leads to infertility in women of reproductive age. Perhaps infertility reflects the reduced expression of Integrin αvβ3 and HOXA10 in endometriosis. Previous studies have shown that administration of letrozole, a non-steroidal Aromatase Inhibitor for Cancer treatment, increased the clinical pregnancy rate in women with endometriosis, but the mechanisms remain to be determined. In this communication, a rat model of endometriosis was established. Animals were treated with letrozole at 2ug/kg of body weight, intragastric administration for 15 consecutive days. Letrozole increased the expression of αvβ3 and HOXA10 in the endometriosis model and endometrial receptivity.Abbreviations: WOI: window of implantation; RGD: Arg-Gly-Asp; HOX: homeobox; E2: estradiol; SPF: specific pathogen-free.

Keywords

HOXA10; Letrozole; endometrial receptivity; endometriosis; integrin αvβ3.

Figures
Products