2. Academic Validation
  3. Ishophloroglucin A, Isolated from Ishige okamurae, Alleviates Dexamethasone-Induced Muscle Atrophy through Muscle Protein Metabolism In Vivo

Ishophloroglucin A, Isolated from Ishige okamurae, Alleviates Dexamethasone-Induced Muscle Atrophy through Muscle Protein Metabolism In Vivo

  • Mar Drugs. 2022 Apr 22;20(5):280. doi: 10.3390/md20050280.
Hye-Won Yang 1,  Seyeon Oh 2,  Dong-Min Chung 3,  Minyoung Seo 3,  Shin Jae Park 3,  You-Jin Jeon 1 4,  Kyunghee Byun 2 5,  BoMi Ryu 1
Affiliations

Affiliations

  • 1 Department of Marine Life Science, School of Marine Biomedical Sciences, Jeju National University, 102 Jejudaehak-ro, Jeju 63243, Korea.
  • 2 Functional Cellular Networks Laboratory, Department of Medicine, Graduate School, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 21999, Korea.
  • 3 Shinwoo Co., Ltd., Jinju 52839, Korea.
  • 4 Marine Science Institute, Jeju National University, Jeju 63333, Korea.
  • 5 Department of Anatomy & Cell Biology, College of Medicine, Gachon University, Incheon 21936, Korea.
PMID: 35621931 DOI: 10.3390/md20050280
Abstract

The in vitro capacity of Ishige okamurae extract (IO) to improve impaired muscle function has been previously examined. However, the mechanism underlying IO-mediated muscle protein metabolism and the role of its component, Ishophloroglucin A (IPA), in mice with dexamethasone (Dexa)-induced muscle atrophy remains unknown. In the present study, we evaluated the effect of IO and IPA supplementation on Dexa-induced muscle atrophy by assessing muscle protein metabolism in gastrocnemius and soleus muscles of mice. IO and IPA supplementation improved the Dexa-induced decrease in muscle weight and width, leading to enhanced grip strength. In addition, IO and IPA supplementation regulated impaired protein synthesis (PI3K and Akt) or degradation (muscle-specific ubiquitin Ligase muscle RING finger and atrogin-1) by modulating mRNA levels in gastrocnemius and soleus muscles. Additionally, IO and IPA upregulated mRNA levels associated with muscle growth activation (transient receptor potential vanilloid type 4 and adenosine A1 receptor) or inhibition (myostatin and Sirtuin 1) in gastrocnemius and soleus muscle tissues of Dexa-induced mice. Collectively, these results suggest that IO and IO-derived IPA can regulate muscle growth through muscle protein metabolism in Dexa-induced muscle atrophy.

Keywords

Ishige okamurae; Ishophloroglucin A; muscle atrophy; muscle growth; muscle protein metabolism.

Figures
Products