2. Academic Validation
  3. Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine

Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine

  • Cancer Cell Int. 2022 Jun 2;22(1):206. doi: 10.1186/s12935-022-02624-9.
Praveen Dhyani 1,  Cristina Quispe 2,  Eshita Sharma 3,  Amit Bahukhandi 4,  Priyanka Sati 5,  Dharam Chand Attri 4,  Agnieszka Szopa 6,  Javad Sharifi-Rad 7,  Anca Oana Docea 8,  Ileana Mardare 9,  Daniela Calina 10,  William C Cho 11
Affiliations

Affiliations

  • 1 Department of Biotechnology, Kumaun University, Bhimtal, Uttarakhand, 263 136, India.
  • 2 Facultad de Ciencias de la Salud, Universidad Arturo Prat, Avda. Arturo Prat 2120, 1110939, Iquique, Chile.
  • 3 Department of Molecular Biology and Biochemistry, Guru Nanak Dev University, Amritsar, Punjab, 143 005, India.
  • 4 G.B. Pant National Institute of Himalayan Environment, Kosi-Katarmal, Almora, Uttarakhand, 263 643, India.
  • 5 Graphic Era University, Dehradun, Uttarakhand, 248 001, India.
  • 6 Chair and Department of Pharmaceutical Botany, Medical College, Jagiellonian University, Medyczna 9, 30-688, Kraków, Poland.
  • 7 Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador. [email protected].
  • 8 Department of Toxicology, University of Medicine and Pharmacy of Craiova, 200349, Craiova, Romania.
  • 9 Department of Public Health and Management, Carol Davila University of Medicine and Pharmacy Bucharest, 050463, Bucharest, Romania.
  • 10 Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349, Craiova, Romania. [email protected].
  • 11 Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong, People's Republic of China. [email protected].
PMID: 35655306 DOI: 10.1186/s12935-022-02624-9
Abstract

Cancer, one of the leading illnesses, accounts for about 10 million deaths worldwide. The treatment of Cancer includes surgery, chemotherapy, radiation therapy, and drug therapy, along with Others, which not only put a tremendous economic effect on patients but also develop drug resistance in patients with time. A significant number of Cancer cases can be prevented/treated by implementing evidence-based preventive strategies. Plant-based drugs have evolved as promising preventive chemo options both in developing and developed nations. The secondary plant metabolites such as Alkaloids have proven efficacy and acceptability for Cancer treatment. Apropos, this review deals with a spectrum of promising Alkaloids such as colchicine, vinblastine, vincristine, vindesine, vinorelbine, and vincamine within different domains of comprehensive information on these molecules such as their medical applications (contemporary/traditional), mechanism of antitumor action, and potential scale-up biotechnological studies on an in-vitro scale. The comprehensive information provided in the review will be a valuable resource to develop an effective, affordable, and cost effective Cancer management program using these Alkaloids.

Keywords

Alkaloids; Anticancer; Antimitotic; Apoptosis; Catharanthus; Colchicum; Microtubule-targeting agents; Vinca.

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