Vindesine
Vindesine is a derivative of Vinblastine (HY-13780). Vindesine binds to and stabilizes tubulin. Vindesine inhibits mitosis in cancer cells and prevents the invasion of normal tissues by malignant cells. Vindesine can be used in cancer research.
For research use only. We do not sell to patients.
- CAS No.: 53643-48-4
- Formula: C43H55N5O7
- Molecular Weight:753.93
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Vindesine binds to intracellular tubulin, thereby inhibiting the assembly of functional microtubules in actively dividing cells[2].
Vindesine potently inhibits mitosis in cancer cell lines[3].
Vindesine inhibits the invasion of malignant cells into normal tissues in vitro[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 53643-48-4
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Molecular Weight 753.93
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Formula C43H55N5O7
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SMILES
CN([C@]1([H])[C@@]23[C@]4([H])[C@](C=CCN4CC3)(CC)[C@@H](O)[C@]1(O)C(N)=O)C(C2=C5)=CC(OC)=C5[C@](C[C@]6([H])C[N@]7C[C@@](CC)(O)C6)(C(OC)=O)C8=C(CC7)C9=CC=CC=C9N8
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Gökbuget N, et al. Vindesine in the treatment of leukaemia. Leuk Lymphoma. 1997;26(5-6):497-506. [Content Brief]
[2]. Sørensen JB, et al. Is there a role for vindesine in the treatment of non-small cell lung cancer?. Invest New Drugs. 1993;11(2-3):103-133. [Content Brief]
[3]. Dhyani P, et al. Anticancer potential of alkaloids: a key emphasis to colchicine, vinblastine, vincristine, vindesine, vinorelbine and vincamine. Cancer Cell Int. 2022;22(1):206. Published 2022 Jun 2. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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