2. Academic Validation
  3. α-Viniferin and ε-Viniferin Inhibited TGF-β1-Induced Epithelial-Mesenchymal Transition, Migration and Invasion in Lung Cancer Cells through Downregulation of Vimentin Expression

α-Viniferin and ε-Viniferin Inhibited TGF-β1-Induced Epithelial-Mesenchymal Transition, Migration and Invasion in Lung Cancer Cells through Downregulation of Vimentin Expression

  • Nutrients. 2022 May 30;14(11):2294. doi: 10.3390/nu14112294.
Wei-Chung Chiou 1,  Cheng Huang 1,  Zi-Jun Lin 2 3,  Lian-Sheng Hong 2 3,  Yu-Heng Lai 4,  Jui-Chieh Chen 5,  Hsiu-Chen Huang 2 3
Affiliations

Affiliations

  • 1 Laboratory Science in Medicine, Department of Biotechnology, National Yang Ming Chiao Tung University, Taipei 11221, Taiwan.
  • 2 Center for Teacher Education, National Tsing Hua University, Hsinchu 300, Taiwan.
  • 3 Department of Applied Science, Nanda Campus, National Tsing Hua University, Hsinchu 300, Taiwan.
  • 4 Department of Chemistry, Chinese Culture University, Taipei 11114, Taiwan.
  • 5 Department of Biochemical Science and Technology, National Chiayi University, Chiayi City 60004, Taiwan.
PMID: 35684095 DOI: 10.3390/nu14112294
Abstract

Resveratrol has well-known Anticancer properties; however, its oligomers, including α-viniferin, ε-viniferin, and kobophenol A, have not yet been well investigated. This is the first study examining the anti-epithelial-mesenchymal transition (EMT) effects of α-viniferin and ε-viniferin on A549, NCI-H460, NCI-H520, MCF-7, HOS, and U2OS cells. The results showed that α-viniferin and ε-viniferin significantly inhibited EMT, invasion and migration in TGF-β1- or IL-1β-induced non-small cell lung Cancer. α-Viniferin and ε-viniferin also reversed TGF-β1-induced Reactive Oxygen Species (ROS), MMP2, vimentin, Zeb1, Snail, p-SMAD2, p-SMAD3, and ABCG2 expression in A549 cells. Furthermore, ε-viniferin was found to significantly inhibit lung metastasis in A549 cell xenograft metastatic mouse models. In view of these findings, α-viniferin and ε-viniferin may play an important role in the prevention of EMT and Cancer metastasis in lung Cancer.

Keywords

TGF-β1; epithelial-mesenchymal transition; nude mice; vimentin; α-viniferin; ε-viniferin.

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