2. Academic Validation
  3. Extravascular rapamycin film inhibits the endothelial-to-mesenchymal transition through the autophagy pathway to prevent vein graft restenosis

Extravascular rapamycin film inhibits the endothelial-to-mesenchymal transition through the autophagy pathway to prevent vein graft restenosis

  • Biomater Adv. 2022 Jun:137:212836. doi: 10.1016/j.bioadv.2022.212836.
Tianshu Chu 1,  Chun Dai 1,  Xiang Li 2,  Lei Gao 3,  Hongyan Yin 4,  Jianjun Ge 5
Affiliations

Affiliations

  • 1 Department of Cardiac Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China.
  • 2 CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, China.
  • 3 Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230031, China.
  • 4 The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230031, China.
  • 5 Department of Cardiac Surgery, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China. Electronic address: [email protected].
PMID: 35929241 DOI: 10.1016/j.bioadv.2022.212836
Abstract

Following vein grafting, the vein must adapt to arterial hemodynamics, which can lead to intimal hyperplasia (IH) and restenosis. Moreover, endothelial-to-mesenchymal transition (EndMT) components are highly associated with IH. Therefore, in this study, we aimed to design an extravascular film loaded with rapamycin (extravascular rapamycin film [ERF]) to limit vein graft stenosis. The film exhibited stable physicochemical properties as well as in vivo and in vitro biocompatibility. In vivo, the film inhibited the EndMT by activating the Autophagy pathway. Moreover, rapamycin enhanced this biological effect. Collectively, these findings highlighted the applicability of ERF as a new therapeutic target for preventing vein graft restenosis.

Keywords

Autophagy; Endothelial-to-mesenchymal transition; Film; Intimal hyperplasia; Rapamycin.

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