2. Academic Validation
  3. Wychimicins, a new class of spirotetronate polyketides from Actinocrispum wychmicini MI503-A4

Wychimicins, a new class of spirotetronate polyketides from Actinocrispum wychmicini MI503-A4

  • J Antibiot (Tokyo). 2022 Oct;75(10):535-541. doi: 10.1038/s41429-022-00560-4.
Tomoyuki Kimura 1,  Maya Umekita 1,  Masaki Hatano 1,  Chigusa Hayashi 1,  Ryuichi Sawa 2,  Masayuki Igarashi 3
Affiliations

Affiliations

  • 1 Institute of Microbial Chemistry (BIKAKEN), 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo, 141-0021, Japan.
  • 2 Institute of Microbial Chemistry (BIKAKEN), 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo, 141-0021, Japan. [email protected].
  • 3 Institute of Microbial Chemistry (BIKAKEN), 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo, 141-0021, Japan. [email protected].
PMID: 36071214 DOI: 10.1038/s41429-022-00560-4
Abstract

In the course of our screening program for new anti-methicillin-resistant Staphylococcus aureus Antibiotics, four novel Antibiotics, termed wychimicins A-D, were isolated from the culture broth of the rare actinomycete Actinocrispum wychmicini strain MI503-AF4. Wychimicins are spirotetronates possessing a macrocyclic 13-membered ring containing trans-decalin and β-D-xylo-hexopyranose moieties connected to C-17 by an O-glycosidic linkage according to MS, NMR and X-ray analyses. In X-ray crystal structure analysis, the Flack constant was 0.10 (11). The stereochemistry of the spirocarbon C-25 was R. Wychimicins had a minimum inhibitory concentration of 0.125-2 µg ml-1 against methicillin-resistant Staphylococcus aureus.

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