2. Academic Validation
  3. Akt isoforms in the immune system

Akt isoforms in the immune system

  • Front Immunol. 2022 Aug 23:13:990874. doi: 10.3389/fimmu.2022.990874.
Mireia Guerau-de-Arellano 1 2 3 4 5,  Zayda L Piedra-Quintero 1,  Philip N Tsichlis 5 6
Affiliations

Affiliations

  • 1 School of Health and Rehabilitation Sciences, Division of Medical Laboratory Science, College of Medicine, Wexner Medical Center, The Ohio State University, Columbus, OH, United States.
  • 2 Institute for Behavioral Medicine Research, The Ohio State University, Columbus, OH, United States.
  • 3 Department of Microbial Infection and Immunity, The Ohio State University, Columbus, OH, United States.
  • 4 Department of Neuroscience, The Ohio State University, Columbus, OH, United States.
  • 5 The Ohio State University Comprehensive Cancer Center, The Ohio State University, Columbus, OH, United States.
  • 6 Department of Cancer Biology and Genetics, The Ohio State University, Columbus, OH, United States.
PMID: 36081513 DOI: 10.3389/fimmu.2022.990874
Abstract

Akt is a PI3K-activated serine-threonine kinase that exists in three distinct isoforms. Akt's expression in most immune cells, either at baseline or upon activation, reflects its importance in the immune system. While Akt is most highly expressed in innate immune cells, it plays crucial roles in both innate and adaptive immune cell development and/or effector functions. In this review, we explore what's known about the role of Akt in innate and adaptive immune cells. Wherever possible, we discuss the overlapping and distinct role of the three Akt isoforms, namely Akt1, Akt2, and Akt3, in immune cells.

Keywords

Akt; Akt1; Akt2; Akt3; immune cells.

Figures