2. Academic Validation
  3. New insights into the anticancer therapeutic potential of maytansine and its derivatives

New insights into the anticancer therapeutic potential of maytansine and its derivatives

  • Biomed Pharmacother. 2023 Sep:165:115039. doi: 10.1016/j.biopha.2023.115039.
Sameen Zafar 1,  Muhammad Armaghan 1,  Khushbukhat Khan 2,  Nazia Hassan 3,  Javad Sharifi-Rad 4,  Solomon Habtemariam 5,  Marek Kieliszek 6,  Monica Butnariu 7,  Iulia-Cristina Bagiu 8,  Radu Vasile Bagiu 9,  William C Cho 10
Affiliations

Affiliations

  • 1 Department of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Punjab, Pakistan.
  • 2 Department of Healthcare Biotechnology, Atta-ur-Rahman School of Applied Biosciences, National University of Sciences and Technology, Islamabad, Punjab, Pakistan. Electronic address: [email protected].
  • 3 Department of Biochemistry, University of Agriculture Faisalabad, Pakistan.
  • 4 Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador. Electronic address: [email protected].
  • 5 Pharmacognosy Research & Herbal Analysis Services UK, University of Greenwich, Central Avenue, Chatham-Maritime, Kent ME4 4TB, UK. Electronic address: [email protected].
  • 6 Department of Food Biotechnology and Microbiology, Institute of Food Sciences, Warsaw University of Life Sciences-SGGW, Nowoursynowska 159 C, 02-776 Warsaw, Poland. Electronic address: [email protected].
  • 7 University of Life Sciences "King Mihai I" from Timisoara, 300645, Calea Aradului 119, Timis, Romania. Electronic address: [email protected].
  • 8 Victor Babes University of Medicine and Pharmacy of Timisoara, Department of Microbiology, Timisoara, Romania; Multidisciplinary Research Center on Antimicrobial Resistance, Timisoara, Romania.
  • 9 Victor Babes University of Medicine and Pharmacy of Timisoara, Department of Microbiology, Timisoara, Romania; Preventive Medicine Study Center, Timisoara, Romania.
  • 10 Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong Special Administrative Region. Electronic address: [email protected].
PMID: 37364476 DOI: 10.1016/j.biopha.2023.115039
Abstract

Maytansine is a pharmacologically active 19-membered ansamacrolide derived from various medicinal Plants and Microorganisms. Among the most studied pharmacological activities of maytansine over the past few decades are Anticancer and anti-bacterial effects. The Anticancer mechanism of action is primarily mediated through interaction with the tubulin thereby inhibiting the assembly of microtubules. This ultimately leads to decreased stability of microtubule dynamics and cause cell cycle arrest, resulting in Apoptosis. Despite its potent pharmacological effects, the therapeutic applications of maytansine in clinical medicine are quite limited due to its non-selective cytotoxicity. To overcome these limitations, several derivatives have been designed and developed mostly by modifying the parent structural skeleton of maytansine. These structural derivatives exhibit improved pharmacological activities as compared to maytansine. The present review provides a valuable insight into maytansine and its synthetic derivatives as Anticancer agents.

Keywords

Antibody-drug conjugate; Anticancer activity; Cytotoxicity; Derivatives; Maytansine; Tubulin instability.

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