2. Academic Validation
  3. Three-Dimensional Gene Regulation Network in Glioblastoma Ferroptosis

Three-Dimensional Gene Regulation Network in Glioblastoma Ferroptosis

  • Int J Mol Sci. 2023 Oct 6;24(19):14945. doi: 10.3390/ijms241914945.
Man Liu 1,  Wenbin Wang 1,  Han Zhang 1,  Jinfang Bi 1,  Baoying Zhang 1,  Tengfei Shi 1,  Guangsong Su 1,  Yaoqiang Zheng 1,  Sibo Fan 1,  Xiaofeng Huang 1,  Bohan Chen 1,  Yingjie Song 1,  Zhongfang Zhao 1,  Jiandang Shi 1,  Peng Li 1,  Wange Lu 1,  Lei Zhang 1
Affiliations

Affiliation

  • 1 State Key Laboratory of Medicinal Chemical Biology, Frontiers Science Center for Cell Responses, College of Life Sciences, Nankai University, Tianjin 300071, China.
PMID: 37834393 DOI: 10.3390/ijms241914945
Abstract

Ferroptosis is an iron-dependent form of cell death, which is reported to be associated with glioma progression and drug sensitivity. Targeting Ferroptosis is a potential therapeutic approach for glioma. However, the molecular mechanism of glioma cell Ferroptosis is not clear. In this study, we profile the change of 3D chromatin structure in glioblastoma Ferroptosis by using HiChIP and study the 3D gene regulation network in glioblastoma Ferroptosis. A combination of an analysis of HiChIP and RNA-seq data suggests that change of chromatin loops mediated by 3D chromatin structure regulates gene expressions in glioblastoma Ferroptosis. Genes that are regulated by 3D chromatin structures include genes that were reported to function in Ferroptosis, like HDM2 and TXNRD1. We propose a new regulatory mechanism governing glioblastoma cell Ferroptosis by 3D chromatin structure.

Keywords

3D chromatin structure; HiChIP; enhancer; ferroptosis; glioblastoma.

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